6-(trideuteriomethyl)-4,4,6-trimethylcyclohex-2-en-1-one | 620943-73-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(trideuteriomethyl)-4,4,6-trimethylcyclohex-2-en-1-one
• 英文别名: 4,4,6-Trimethyl-6-(trideuteriomethyl)cyclohex-2-en-1-one；4,4,6-trimethyl-6-(trideuteriomethyl)cyclohex-2-en-1-one
• CAS: 620943-73-9
• 化学式: C₁₀H₁₆O
• 分子量: 155.213
• InChiKey: AVJYBPVWUQFBIL-HPRDVNIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-(trideuteriomethyl)-4,4,6-trimethylcyclohex-2-en-1-one 在 吡啶 、 4-二甲氨基吡啶 、 碘 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 以93%的产率得到2-iodo-6-(trideuteriomethyl)-4,4,6-trimethylcyclohex-2-en-1-one
  参考文献：
  名称：

  用于可逆添加氧基和硫基亲核试剂的新型迈克尔受体基团的鉴定。Avrainvillamide 3-Alkylidene-3H-indole 1-Oxide 官能团的合成和反应性

  摘要：

  在天然存在的生物碱 avrainvillamide 中发现的 3-亚烷基-3H-吲哚 1-氧化物官能团是通过交叉偶联还原缩合序列合成的，并且发现可以可逆地添加氧基和硫基亲核试剂。

  DOI：

  10.1021/ja0372006
• 作为产物：
  描述：

  4,4-二甲基-2-环己基-1-酮 、 alkaline earth salt of/the/ methylsulfuric acid 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 24.17h， 生成 6-(trideuteriomethyl)-4,4,6-trimethylcyclohex-2-en-1-one
  参考文献：
  名称：

  用于可逆添加氧基和硫基亲核试剂的新型迈克尔受体基团的鉴定。Avrainvillamide 3-Alkylidene-3H-indole 1-Oxide 官能团的合成和反应性

  摘要：

  在天然存在的生物碱 avrainvillamide 中发现的 3-亚烷基-3H-吲哚 1-氧化物官能团是通过交叉偶联还原缩合序列合成的，并且发现可以可逆地添加氧基和硫基亲核试剂。

  DOI：

  10.1021/ja0372006

文献信息

• SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF
  申请人：Myers Andrew G.

  公开号：US20110166170A1

  公开（公告）日：2011-07-07

  The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

  本文介绍了自然产物avrainvillamide和stephacidin B的合成方法。其中，avrainvillamide的α,β-不饱和亚硝基功能团和其3-烷基亚甲基-3H-吲哚1-氧化物核心被证明能够与杂原子型亲核试剂共价、可逆结合。这种能力可能使这些分子能够结合活性位点的亲核试剂，并为设计有效且选择性的酶抑制剂提供基础。avrainvillamide和其二聚体stephacidin B均已被报道具有抗增殖活性，而avrainvillamide还被报道对多重耐药菌具有抗菌活性。研究发现，avrainvillamide能够靶向细胞骨架连接膜蛋白（CLIMP-63），从而防止细胞进行有丝分裂。本发明提供了这些天然产物以及它们的类似物和功能核心的合成方法。这些化合物可以用于治疗癌症、自身免疫性疾病和细菌感染等疾病。
• SYNTHESIS OF AVRAINVILLAMIDE, STREPHACIDIN B, AND ANALOGUES THEREOF
  申请人：Myers Andrew G.

  公开号：US20090143581A1

  公开（公告）日：2009-06-04

  The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

  本文提供了天然产物avrinvillamide和stephacidin B的合成方法。avrinvillamide的α，β-不饱和亚硝基功能和其3-烷基亚甲基-3H-吲哚1-氧化物核心被证明可以共价可逆地结合到基于杂原子的亲核试剂上。这种能力可能使这些分子能够结合到活性位点的亲核试剂，并为设计有效和选择性的酶抑制剂提供基础。avrinvillamide和其二聚体stephacidin B均已报道具有抗增殖活性，avrinvillamide也已报道具有对多药耐药细菌的抗菌活性。发现avrinvillamide的靶点是细胞骨架连接膜蛋白(CLIMP-63)，从而防止细胞进行有丝分裂。本发明提供了这些天然产物以及它们的类似物和功能核心的合成方法。本发明的化合物可以用于治疗癌症、自身免疫性疾病和细菌感染等疾病。
• US7902196B2
  申请人：——

  公开号：US7902196B2

  公开（公告）日：2011-03-08
• [EN] SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF<br/>[FR] SYNTHESE D'AVRAINVILLAMIDE, DE STEPHACIDINE B ET D'ANALOGUES CORRESPONDANTS
  申请人：HARVARD COLLEGE

  公开号：WO2006102097A2

  公开（公告）日：2006-09-28

  [EN] The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The a,ß-unsaturated nitrone functionality of avrainvillamide and its 3- alkylidene-3H-indole 1 -oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enayme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.
  [FR] L'invention concerne la synthèse de produits naturels appelés avrainvillamide et stéphacidine B. On a observé que la fonctionnalité nitrone a,ß-insaturée de l'avrainvillamide et de son noyau 3-alkylidène-3H-indole 1-oxyde se lie de manière covalente et réversible à des nucléophiles à base d'hétéroatomes. Cette capacité peut permettre à ces molécules de se lier à des nucléophiles de sites actifs et peut fournir une base pour la conception d'inhibiteurs enzymatiques puissants et sélectifs. On a établi que l'avrainvillamide et sa stéphacidine B dimérique présentent une activité antiproliférative, et que l'avrainvillamide présente une activité antimicrobienne dirigée contre les bactéries multirésistantes aux médicaments. On a découvert que l'avrainvillamide est ciblé sur la protéine membranaire de liaison au cytosquelette (CLIMP-63), ce qui empêche les cellules de subir la mitose. L'invention concerne la synthèse de ces produits naturels ainsi que des analogues de ces produits naturels et leurs noyaux fonctionnels. Les composés de l'invention peuvent être utilisés dans le traitement de maladies telles que le cancer, les maladies auto-immunes et l'infection bactérienne.
• Identification of a Novel Michael Acceptor Group for the Reversible Addition of Oxygen- and Sulfur-Based Nucleophiles. Synthesis and Reactivity of the 3-Alkylidene-3<i>H</i>-indole 1-Oxide Function of Avrainvillamide
  作者：Andrew G. Myers、Seth B. Herzon

  DOI：10.1021/ja0372006

  日期：2003.10.1

  The 3-alkylidene-3H-indole 1-oxide functional group found in the naturally occurring alkaloid avrainvillamide has been synthesized by a cross coupling-reductive condensation sequence and found to undergo reversible addition of oxygen- and sulfur-based nucleophiles.

  在天然存在的生物碱 avrainvillamide 中发现的 3-亚烷基-3H-吲哚 1-氧化物官能团是通过交叉偶联还原缩合序列合成的，并且发现可以可逆地添加氧基和硫基亲核试剂。