Methyl 2-amino-4-bromo-5-hydroxy-furo[2,3-f]quinoline-3-carboxylate | 1273318-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 2-amino-4-bromo-5-hydroxy-furo[2,3-f]quinoline-3-carboxylate
• 英文别名: methyl 2-amino-4-bromo-5-hydroxyfuro[2,3-f]quinoline-3-carboxylate
• CAS: 1273318-82-3
• 化学式: C₁₃H₉BrN₂O₄
• 分子量: 337.129
• InChiKey: XKDRVHWZEFSQIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  98.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 2-(7-bromo-5,8-dioxo-5,8-dihydroquinolin-6-yl)-2-cyanoacetate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 Methyl 2-amino-4-bromo-5-hydroxy-furo[2,3-f]quinoline-3-carboxylate
  参考文献：
  名称：

  Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols

  摘要：

  Furo[2,3-f]quinolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many furo[2,3-f]quinolin-5-ols showed good antifungal activity. The results suggest that furo[2,3-f]quinolin-5-ols would be promising antifungal agents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.058

文献信息

• Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols
  作者：Chung-Kyu Ryu、Yang Hui Kim、Ji-Hee Nho、Jung An Hong、Joo Hee Yoon、Aram Kim

  DOI：10.1016/j.bmcl.2010.12.058

  日期：2011.2

  Furo[2,3-f]quinolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many furo[2,3-f]quinolin-5-ols showed good antifungal activity. The results suggest that furo[2,3-f]quinolin-5-ols would be promising antifungal agents. (C) 2010 Elsevier Ltd. All rights reserved.