3-(2,2-dimethoxyethoxy)-2-pyridinemethanol | 136423-85-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2,2-dimethoxyethoxy)-2-pyridinemethanol
• 英文别名: [3-(2,2-Dimethoxyethoxy)pyridin-2-yl]methanol
• CAS: 136423-85-3
• 化学式: C₁₀H₁₅NO₄
• 分子量: 213.233
• InChiKey: GLJMNNIYTGZRSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(2,2-dimethoxyethoxy)-2-pyridinemethanol 在 manganese(IV) oxide 作用下， 以 乙二醇二甲醚 为溶剂， 反应 1.0h， 以82%的产率得到3-(2,2-dimethoxyethoxy)-2-pyridinecarboxaldehyde
  参考文献：
  名称：

  Guanylhydrazones of 3-substituted 2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy) acetaldehyde as prostanoid biosynthesis and platelet aggregation inhibitors

  摘要：

  Some guanylhydrazones of (3-benzyloxy)-2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy)acetaldehyde were prepared in order to evaluate their possible activity as inhibitors of prostanoid biosynthesis in human serum. Only those products of the second group without the carboxylic function reduced prostanoid generation in vitro at the highest concentration; they also inhibited platelet aggregation induced by arachidonic acid and U-46619. The results suggest that these compounds are both inhibitors of cyclooxygenase and cyclic endoperoxides/TxA2 platelet receptor antagonists.

  DOI：

  10.1016/0223-5234(91)90107-x
• 作为产物：
  描述：

  2-溴-1,1-二甲氧基乙烷 、 3-羟基-2-羟甲基吡啶盐酸盐 在 sodium ethanolate 作用下， 生成 3-(2,2-dimethoxyethoxy)-2-pyridinemethanol
  参考文献：
  名称：

  Guanylhydrazones of 3-substituted 2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy) acetaldehyde as prostanoid biosynthesis and platelet aggregation inhibitors

  摘要：

  Some guanylhydrazones of (3-benzyloxy)-2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy)acetaldehyde were prepared in order to evaluate their possible activity as inhibitors of prostanoid biosynthesis in human serum. Only those products of the second group without the carboxylic function reduced prostanoid generation in vitro at the highest concentration; they also inhibited platelet aggregation induced by arachidonic acid and U-46619. The results suggest that these compounds are both inhibitors of cyclooxygenase and cyclic endoperoxides/TxA2 platelet receptor antagonists.

  DOI：

  10.1016/0223-5234(91)90107-x

文献信息

• Guanylhydrazones of 3-substituted 2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy) acetaldehyde as prostanoid biosynthesis and platelet aggregation inhibitors
  作者：N Desideri、I Sestili、S Manarini、C Cerletti、ML Stein

  DOI：10.1016/0223-5234(91)90107-x

  日期：1991.6

  Some guanylhydrazones of (3-benzyloxy)-2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy)acetaldehyde were prepared in order to evaluate their possible activity as inhibitors of prostanoid biosynthesis in human serum. Only those products of the second group without the carboxylic function reduced prostanoid generation in vitro at the highest concentration; they also inhibited platelet aggregation induced by arachidonic acid and U-46619. The results suggest that these compounds are both inhibitors of cyclooxygenase and cyclic endoperoxides/TxA2 platelet receptor antagonists.