2,2-bis(4-methoxyphenyl)-5-phenylthio-6-hydroxy-2H-naphtho[1,2-b]pyran | 194940-71-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2,2-bis(4-methoxyphenyl)-5-phenylthio-6-hydroxy-2H-naphtho[1,2-b]pyran
• 英文别名: 2,2-Bis(4-methoxyphenyl)-5-phenylsulfanylbenzo[h]chromen-6-ol
• CAS: 194940-71-1
• 化学式: C₃₃H₂₆O₄S
• 分子量: 518.633
• InChiKey: QEDMQITUAKOQGA-UHFFFAOYSA-N

物化性质

• 沸点：
  680.9±55.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  73.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2-bis(4-methoxyphenyl)-5-phenylthio-6-hydroxy-2H-naphtho[1,2-b]pyran 、 乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2,2-bis(4-methoxyphenyl)-5-phenylthio-6-acetoxy-2H-naphtho[1,2-b]pyran
  参考文献：
  名称：

  NOVEL SUBSTITUTED NAPHTHOPYRANS

  摘要：

  公开号：

  EP0994871B1
• 作为产物：
  描述：

  1,1-双(4-甲氧基苯基)-2-丙炔-1-醇 、 2-phenylsulfanyl-naphthalene-1,4-diol 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 2,2-bis(4-methoxyphenyl)-5-phenylthio-6-hydroxy-2H-naphtho[1,2-b]pyran
  参考文献：
  名称：

  NOVEL SUBSTITUTED NAPHTHOPYRANS

  摘要：

  公开号：

  EP0994871B1

文献信息

• Mechanophoric medical product
  申请人：Aesculap AG

  公开号：US10758643B2

  公开（公告）日：2020-09-01

  A medical product which contains a mechanophore, and the use of a mechanophore for producing a medical product.

  含有机械噬菌体的医疗产品，以及使用机械噬菌体生产医疗产品。
• MECHANOPHORES MEDIZINPRODUKT
  申请人：Aesculap AG

  公开号：EP3331581B1

  公开（公告）日：2020-07-08
• Mechanophoric Medical Product
  申请人：Aesculap AG

  公开号：US20190151502A1

  公开（公告）日：2019-05-23

  A medical product which contains a mechanophore, and the use of a mechanophore for producing a medical product.
• PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS
  申请人：Alcon Inc.

  公开号：US20210284806A1

  公开（公告）日：2021-09-16

  The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.
• METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES
  申请人：Alcon Inc.

  公开号：US20210371731A1

  公开（公告）日：2021-12-02

  Described herein is a cost-effective and time-efficient method for producing photochromic contact lenses, in particular, preferably photochromic silicone hydrogel contact lenses, from a polymerizable composition comprising an unique selection and combination of main polymerizable components, a photochromic compound and a visible-light photoinitiator, based on the Lightstream Technology™. This invention also provides photochromic contact lenses or more preferably photochromic silicone hydrogel contact lenses made according to a method of the invention. A photochromic contact lens of the invention is capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light (HEVL) (with wavelengths from 380 nm to 440 nm).