2-chlorosulfonyl-thenoyltrifluoroacetone | 147394-70-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chlorosulfonyl-thenoyltrifluoroacetone
• 英文别名: 5-(4,4,4-Trifluoro-3-oxobutanoyl)thiophene-2-sulfonyl chloride；5-(4,4,4-trifluoro-3-oxobutanoyl)thiophene-2-sulfonyl chloride
• CAS: 147394-70-5
• 化学式: C₈H₄ClF₃O₄S₂
• 分子量: 320.698
• InChiKey: VVPHPMQVTQBXMY-UHFFFAOYSA-N

物化性质

• 沸点：
  416.9±45.0 °C(Predicted)
• 密度：
  1.656±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-chlorosulfonyl-thenoyltrifluoroacetone 在 Carbonate buffer 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  A chiral Eu3+–thienoyltrifluoroacetone complex on an avidin tetramer: luminescence and CD studies on the supramolecular protein–metal chelate complex

  摘要：

  通过结合生物素连接的噻吩基三氟乙酰丙酮，构建了一种手性的Eu3+络合物，并将其嵌入到四聚体抗生物素蛋白的生物素结合位点中。

  DOI：

  10.1039/b001908i
• 作为产物：
  描述：

  2-噻吩甲酰三氟丙酮 在 氯磺酸 作用下， 反应 5.0h， 以5.1 g的产率得到2-chlorosulfonyl-thenoyltrifluoroacetone
  参考文献：
  名称：

  高荧光β-二酮-eur螯合物的合成及其在血清总甲状腺素的时间分辨荧光免疫分析中的实用性。

  摘要：

  合成了一种新的高荧光β-二酮-eur螯合物，并用作示踪剂，开发了一种时间分辨的荧光免疫测定法（TRFIA），用于检测血清总甲状腺素（T4）。四齿β-二酮螯合剂1,1-双（噻吩-2'-基）-4,4,5,5,6,6,7,7-八氟癸烷-1,3,8,10-四酮（BTOT ），在结构上由两个单元的壬基三氟丙酮（TTA）衍生物组成，但在存在过量Eu3 +的情况下，与原始TTA分子相比，荧光表达大大增强。在水溶液中研究了BTOT che螯合物的发光性质。BTOT的氯磺酰化得到1，10-双（5'-氯磺基噻吩-2'-基）-4,4,5,5,6,6,7,7-八氟癸烷-1,3,8,10-四酮（BCTOT），它可能与蛋白质（即 链霉亲和素或BSA-T4偶联物），并用作TRFIA的示踪剂。尽管在缓冲水溶液（50 mmoVLTris-HCl; pH，8.0）中可以检测到非常低的BCTOT-Eu络合物（约1.07 x 10（-12）mol

  DOI：

  10.1021/ac025727f

文献信息

• [EN] UREA SUBSTITUTED SULPHONAMIDE DERIVATIVES<br/>[FR] DERIVES DE SULFONAMIDE SUBSTITUES PAR UREE
  申请人：BIOTIE THERAPIES CORP

  公开号：WO2010146236A1

  公开（公告）日：2010-12-23

  The present invention relates to sulphonamide derivatives, whith a urea moiety. The invention also relates to the use of the derivatives as inhibitors of collagen receptor integrins, especially α2β1 integrin inhibitors e.g. in connection with diseases and medical conditions that involve the action of cells and platelets expressing collagen receptors, their use as a medicament, e.g. for the treatment of thrombosis, inflammation, cancer and vascular diseases, pharmaceutical compositions containing them and a process for preparing them. The sulphonamide derivatives have the general formula (I) or (I').

  本发明涉及含有脲基的磺胺类衍生物。该发明还涉及将这些衍生物用作胶原受体整合素的抑制剂，特别是α2β1整合素抑制剂，例如在涉及表达胶原受体的细胞和血小板的疾病和医疗状况中使用，其用作药物，例如用于治疗血栓形成、炎症、癌症和血管疾病，含有它们的药物组合物以及制备它们的方法。这些磺胺类衍生物具有一般式(I)或(I')。
• UREA SUBSTITUTED SULPHONAMIDE DERIVATIVES
  申请人：Koivunen Jarkko Tapani

  公开号：US20120196884A1

  公开（公告）日：2012-08-02

  The present invention relates to sulphonamide derivatives, whith a urea moiety. The invention also relates to the use of the derivatives as inhibitors of collagen receptor integrins, especially α2β1 integrin inhibitors e.g. in connection with diseases and medical conditions that involve the action of cells and platelets expressing collagen receptors, their use as a medicament, e.g. for the treatment of thrombosis, inflammation, cancer and vascular diseases, pharmaceutical compositions containing them and a process for preparing them. The sulphonamide derivatives have the general formula (I) or (I′).

  本发明涉及含有尿素基团的磺酰胺衍生物。本发明还涉及将这些衍生物用作胶原受体整合素的抑制剂，特别是α2β1整合素抑制剂，例如在涉及表达胶原受体的细胞和血小板的疾病和医疗状况中，将其用作药物，例如用于治疗血栓形成、炎症、癌症和血管疾病，包含它们的制药组合物以及制备它们的过程。磺酰胺衍生物具有通式（I）或（I′）。
• SPHERICAL PHOSPHOR, SEALING MATERIAL FOR WAVELENGTH-CONVERSION-TYPE SOLAR BATTERIES, SOLAR BATTERY MODULE, AND PROCESS FOR MANUFACTURE OF THOSE
  申请人：Hitachi Chemical Company, Ltd.

  公开号：EP2650342A1

  公开（公告）日：2013-10-16

  A spherical phosphor includes a fluorescent substance having a maximum excitation wavelength of 400 nm or longer; and a transparent material containing the fluorescent substance, in which, in an excitation spectrum, an excitation spectral intensity in a wavelength region of from 340 nm to 380 nm is 50% or higher of an excitation spectral intensity at a maximum excitation wavelength. A wavelength conversion-type photovoltaic cell sealing material includes a light-permeable resin composition layer that contains the spherical phosphor and a sealing resin.

  球形荧光粉包括最大激发波长为 400 纳米或更长的荧光物质；以及含有该荧光物质的透明材料，在激发光谱中，340 纳米至 380 纳米波长区域内的激发光谱强度是最大激发波长下激发光谱强度的 50%或更高。波长转换型光伏电池密封材料包括透光树脂成分层，其中包含球形荧光粉和密封树脂。
• Chlorosulfonation of 2-acylthiophenes: an examination on the reaction regiochemistry
  作者：Arturo Arduini、Andrea Pochini、Andrea Secchi、Franco Ugozzoli

  DOI：10.1016/s0040-4039(03)01326-1

  日期：2003.7

  Chlorosulfonation of thenoyltrifluoroacetone with neat chlorosulfuric acid was found to give a 25:75 mixture of 3- and 2-chlorosulfonated thenoyltrifluoroacetone isomers in 33% overall yield. The use of dichloromethane as solvent for the chlorosulfonation reaction gave only the 2-chlorosulfonated isomer in 45% yield. On the contrary, the reaction of 2-acetylthiophene with neat chlorosulfuric acid gave only the 3-chlorosulfonated-5-acetylthiophene in 35% yield. The identity of these chlorosulfonated compounds was unambiguously established by NMR techniques and confirmed by the crystal structure determination of the 2-chlorosulfonated isomer. (C) 2003 Elsevier Ltd. All rights reserved.
• SPHERICAL PHOSPHOR, WAVELENGTH CONVERSION-TYPE PHOTOVOLTAIC CELL SEALING MATERIAL, PHOTOVOLTAIC CELL MODULE, AND PRODUCTION METHODS THEREOF
  申请人：Okaniwa Kaoru

  公开号：US20130255778A1

  公开（公告）日：2013-10-03

  A spherical phosphor includes a fluorescent substance having a maximum excitation wavelength of 400 nm or longer; and a transparent material containing the fluorescent substance, in which, in an excitation spectrum, an excitation spectral intensity in a wavelength region of from 340 nm to 380 nm is 50% or higher of an excitation spectral intensity at a maximum excitation wavelength. A wavelength conversion-type photovoltaic cell sealing material includes a light-permeable resin composition layer that contains the spherical phosphor and a sealing resin.