4,4'-dioxo-1,4,1',4'-tetrahydro-[6,6']biquinolinyl-2,2'-dicarboxylic acid dimethyl ester | 52979-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,4'-dioxo-1,4,1',4'-tetrahydro-[6,6']biquinolinyl-2,2'-dicarboxylic acid dimethyl ester
• 英文别名: methyl 6-(2-methoxycarbonyl-4-oxo-1H-quinolin-6-yl)-4-oxo-1H-quinoline-2-carboxylate
• CAS: 52979-98-3
• 化学式: C₂₂H₁₆N₂O₆
• 分子量: 404.379
• InChiKey: RVBCSBDJFRKVMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4,4'-dioxo-1,4,1',4'-tetrahydro-[6,6']biquinolinyl-2,2'-dicarboxylic acid dimethyl ester 、 光气 以77%的产率得到
  参考文献：
  名称：

  POLANC S.; COLNAR C., J. SERB. CHEM. SOC., 52,(1987) N 1, 11-15

  摘要：

  DOI：
• 作为产物：
  描述：

  联苯胺 在 四磷十氧化物 作用下， 以 甲醇 为溶剂， 生成 4,4'-dioxo-1,4,1',4'-tetrahydro-[6,6']biquinolinyl-2,2'-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles

  摘要：

  The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.

  DOI：

  10.1021/jo070181o

文献信息

• POLANC S.; COLNAR C., J. SERB. CHEM. SOC., 52,(1987) N 1, 11-15
  作者：POLANC S.、 COLNAR C.

  DOI：——

  日期：——
• A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles
  作者：Daniel Zewge、Cheng-yi Chen、Curtis Deer、Peter G. Dormer、Dave L. Hughes

  DOI：10.1021/jo070181o

  日期：2007.5.1

  The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.