disodium-2-amino naphthalene-1,5-disulfonate salt | 19532-03-7

• 物质功能分类: 有机原料 - 氨基化合物 - 磺酸类氨基化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: disodium-2-amino naphthalene-1,5-disulfonate salt
• 英文别名: Sodium hydrogen 2-aminonaphthalene-1,5-disulphonate；sodium;2-aminonaphthalene-1,5-disulfonate
• CAS: 19532-03-7
• 化学式: C₁₀H₇NO₆S₂*2Na
• 分子量: 347.28
• InChiKey: NBXIPKKZZYZDKR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.77
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  157
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26
• 危险类别码：
  R36
• WGK Germany：
  2
• RTECS号：
  QJ6135000

反应信息

• 作为反应物：
  描述：

  disodium-2-amino naphthalene-1,5-disulfonate salt 在 palladium 10% on activated carbon 、 氢气 、 sodium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 4.0h， 生成 disodium 2-[(3-aminobenzoyl)amino]naphthalene-1,5-disulfonate salt
  参考文献：
  名称：

  丙烯酰胺基萘磺酸盐类化合物作为一类新型乙酰肝素酶抑制剂

  摘要：

  寻找用于癌症治疗的抗转移剂可能涉及新化合物维持组织细胞外基质完整性的能力。在已知因素中，乙酰肝素酶（一种负责硫酸乙酰肝素裂解的内切葡糖醛酸糖苷酶）是一个很有希望的靶标，其抑制作用可能成为转移性癌变机制的强大障碍。文献中报道的一些苏拉明衍生物的抗转移活性表明乙酰肝素酶可能参与其中。为了证实这种假设，我们研究了FCE27266，这是一种以其抗血管生成和抗转移特性而闻名的分子。还合成和研究了其他新的衍生物。我们的发现表明FCE27266以及某些衍生物具有很强的乙酰肝素酶抑制活性，并且没有细胞毒性。而且，17a）还导致某些促血管生成因子的基因表达降低也呈阳性。

  DOI：

  10.1016/j.bmcl.2017.08.013

文献信息

• DERIVATIVES OF THE DISODIUM 2,2'-{CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(1-METHYL-1H-PYRROLE-4,2-DIYL)CARBONYLIMINO]}DINAPHTHALENE-1,5-DISULFONATE SALT AND RELATED COMPOUNDS AS HEPARANASE INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Leadiant Biosciences SA

  公开号：EP3381897A1

  公开（公告）日：2018-10-03

  The present invention relates to ureido derivatives of naphtalenesulfonic acids having an anti-heparanase activity. In particular, it relates to compounds of formula (I) for use in the treatment of diseases where an inhibition of heparanase is desired, in particular cancer. The present invention also relates in particular to derivatives of the disodium 2,2'-carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds.

  本发明涉及具有抗肝素酶活性的萘磺酸脒衍生物。特别是，它涉及用于治疗需要抑制肝素酶的疾病的公式（I）化合物的用途，尤其是癌症。本发明还特别涉及二钠2,2'-[脒基(1-甲基-1H-吡咯-4,2-二基)脒基]二硫}二萘-1,5-二磺酸盐及其相关衍生物。
• Reactive dyes containing a linkage
  申请人：BASF Aktiengesellschaft

  公开号：US06359121B1

  公开（公告）日：2002-03-19

  A reactive disazo dye of the formula (I) D1—Y—D2 wherein each of D1 and D2 is a chromophore of the formula (II) in which X is fluorine, chlorine or optionally substituted pyridinium, an SO3H is present in the 5-or 6-position of the naphthalene nucleus, n is 0 or 1, and Y is a bridging group or a sulphonic acid salt of the dye of formula (I). The dyes may be used for dyeing, printing or ink-jet printing, for example, of textile materials and paper and are particularly valuable for coloring cellulosic textile materials.

  一种具有以下化学式（I）的反应性二氮酰胺染料：D1—Y—D2，其中D1和D2分别是具有以下化学式（II）的色团，其中X为氟、氯或可选择取代的吡啶基，萘环的5-位或6-位存在SO3H基团，n为0或1，Y是化学式（I）染料的桥接基团或磺酸盐。这些染料可用于染色、印刷或喷墨印刷，例如纺织材料和纸张，特别适用于着色纤维素纺织品。
• Synthesis and binding mode of heterocyclic analogues of suramin inhibiting the human basic fibroblast growth factor
  作者：Fabrizio Manetti、Valentina Cappello、Maurizio Botta、Federico Corelli、Nicola Mongelli、Giovanni Biasoli、Andrea Lombardi Borgia、Marina Ciomei

  DOI：10.1016/s0968-0896(98)00052-2

  日期：1998.7

  The design, synthesis, and biological evaluation of a series of pyrrole and pyrazole congeners 2 of suramin, directed toward the development and identification of new ligands that complex the human fibroblast growth factor (bFGF), thereby inhibiting tumor-promoted angiogenesis, is reported. Compounds 2 were evaluated for their ability to inhibit binding of bFGF to its receptor, in vivo bFGF-induced angiogenesis, and neovascularization of the chorioallantoic membrane in comparison with suramin. These assays showed that ligands 2 exhibit moderate to good activity, comparable to that of suramin, and are less toxic than suramin itself. In this study, affinity data of ligands in combination with the crystal structure of bFGF were used to explain structure-affnity relationships and to gain an insight into the possible mode of ligand-protein interaction. Due to the lack of experimental structural data on the ligand-bFGF complexes, molecular mechanics techniques were used to obtain putative bioactive conformations and to generate docked complexes with the three-dimensional structure of bFGF. These experiments led to suggest that compounds 2 give rise to 1:1 complexes with bFGF through an unprecedented, bidentate attachment of their naphthylsulfonate groups to two main domains, commonly referred to as the heparin binding site and the receptor binding site, on bFGF, thus preventing the interaction of the growth factor with its receptor. (C) 1998 Elsevier Science Ltd. All rights reserved.
• CN116715979
  申请人：——

  公开号：——

  公开（公告）日：——