δ-Iod-α-benzyl-γ-valerolacton | 1729-21-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: δ-Iod-α-benzyl-γ-valerolacton
• 英文别名: 3-Benzyl-5-(iodomethyl)oxolan-2-one
• CAS: 1729-21-1
• 化学式: C₁₂H₁₃IO₂
• 分子量: 316.139
• InChiKey: CKQGFWUXIGENQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  δ-Iod-α-benzyl-γ-valerolacton 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-(Azidomethyl)-3-benzyloxolan-2-one
  参考文献：
  名称：

  ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF

  摘要：

  公开号：

  EP2233467B1
• 作为产物：
  描述：

  2-benzyl-4-pentenoic acid 在 碳酸氢钠 、 碘 、 potassium iodide 作用下， 以 乙醚 、 水 为溶剂， 反应 1.0h， 生成 δ-Iod-α-benzyl-γ-valerolacton
  参考文献：
  名称：

  ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF

  摘要：

  公开号：

  EP2233467B1

文献信息

• Alpha-Amino-N-Substituted Amides, Pharmaceutical Composition Containing Them and Uses Thereof
  申请人：Nan Fajun

  公开号：US20110021624A1

  公开（公告）日：2011-01-27

  Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
• US8470763B2
  申请人：——

  公开号：US8470763B2

  公开（公告）日：2013-06-25
• ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：EP2233467B1

  公开（公告）日：2012-09-19
• Sodium nitrite (NaNO2) catalysed iodo-cyclisation of alkenes and alkynes using molecular oxygen
  作者：Hongjun Liu、Yuanhang Pan、Choon-Hong Tan

  DOI：10.1016/j.tetlet.2008.05.013

  日期：2008.7

  We have developed a convenient iodo-cyclisation reaction using NaNO(2) as catalyst and molecular oxygen as the terminal oxidant. The reactive species, acetyl hypoiodite (IOAc), was generated in situ from TBAI and AcOH. The iodo-cyclisation reaction with a range of alkenes and alkynes gave good to excellent yields. Iodo-amination products can also be obtained using carbarnates prepared from commercially available allylic alcohols and alkynic alcohols. (c) 2008 Elsevier Ltd. All rights reserved.