ethyl 6-(1-(4-methoxyphenyl)-1-oxopropan-2-yl)-4-methyl-5-phenylpicolinate | 1095874-52-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 6-(1-(4-methoxyphenyl)-1-oxopropan-2-yl)-4-methyl-5-phenylpicolinate
• 英文别名: Ethyl 6-[1-(4-methoxyphenyl)-1-oxopropan-2-yl]-4-methyl-5-phenylpyridine-2-carboxylate
• CAS: 1095874-52-4
• 化学式: C₂₅H₂₅NO₄
• 分子量: 403.478
• InChiKey: KTCHFOGEMHTIAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  ethyl (2Z,4E)-2-azido-4-methyl-5-phenylpenta-2,4-dienoate 、 acetyl p-anisoyldiazomethane 在 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 2.5h， 以85%的产率得到ethyl 6-(1-(4-methoxyphenyl)-1-oxopropan-2-yl)-4-methyl-5-phenylpicolinate
  参考文献：
  名称：

  A Cascade Approach to Pyridines from 2-Azido-2,4-dienoates and α-Diazocarbonyl Compounds

  摘要：

  A one-pot synthesis of substituted pyridines via a cascade reaction of 2-azido-24-dienoates with alpha-diazocarbonyl compounds and triphenylphosphine is reported. The process involves a Staudinger-Meyer reaction, a Wolff rearrangement, ail aza-Wittig reaction, and an electrocyclic ring- closure. The procedure is general and efficient. The substrates are readily available.

  DOI：

  10.1021/jo802159g

文献信息

• A Cascade Approach to Pyridines from 2-Azido-2,4-dienoates and α-Diazocarbonyl Compounds
  作者：Zheng-Bo Chen、Deng Hong、Yan-Guang Wang

  DOI：10.1021/jo802159g

  日期：2009.1.16

  A one-pot synthesis of substituted pyridines via a cascade reaction of 2-azido-24-dienoates with alpha-diazocarbonyl compounds and triphenylphosphine is reported. The process involves a Staudinger-Meyer reaction, a Wolff rearrangement, ail aza-Wittig reaction, and an electrocyclic ring- closure. The procedure is general and efficient. The substrates are readily available.