3-aminomethyl-pentan-1-ol | 231282-15-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-aminomethyl-pentan-1-ol
• 英文别名: 4-amino-3-ethylbutanol；N-(2-Hydroxyethyl)butylamin；3-(Aminomethyl)pentan-1-ol
• CAS: 231282-15-8
• 化学式: C₆H₁₅NO
• mdl: MFCD19205094
• 分子量: 117.191
• InChiKey: XRMZDFLZTLVQKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯酐 、 3-aminomethyl-pentan-1-ol 生成 2-(2-ethyl-4-hydroxybutyl)phthalimide
  参考文献：
  名称：

  Further Syntheses of Primaquine Analogs¹

  摘要：

  DOI：

  10.1021/ja01623a039
• 作为产物：
  描述：

  rac-ethyl 3-cyanopentanoate 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 3-aminomethyl-pentan-1-ol
  参考文献：
  名称：

  Further Syntheses of Primaquine Analogs¹

  摘要：

  DOI：

  10.1021/ja01623a039

文献信息

• PYRIDONE DERIVATIVE HAVING TETRAHYDROPYRANYL METHYL GROUP
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3168219A1

  公开（公告）日：2017-05-17

  It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl. [Solution] The present invention provides a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification).

  本发明旨在提供一种新型化合物或其盐，或该化合物或其盐的结晶，该化合物或其盐可抑制 Axl，并可用于治疗由 Axl 功能亢进引起的疾病、治疗与 Axl 功能亢进相关的疾病和/或治疗涉及 Axl 功能亢进的疾病。 [解决方案］ 本发明提供一种吡啶酮衍生物，该衍生物具有下式（I）所代表的具有各种取代基的四氢吡喃甲基，或其盐，或该化合物或该盐的结晶（其中R1、R2、R3、R4、R5、W、X、Y和Z各自如说明书中所定义）。
• Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
  申请人：INSTITUTO MEXICANO DEL PETROLEO

  公开号：US10125226B2

  公开（公告）日：2018-11-13

  A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.

  该工艺包括两个阶段，第一阶段使用烷基磺酰氯或芳基磺酰氯获得更好的离去基团，第二阶段使用仲胺或叔胺进行亲核取代，从而获得双官能化的三嵌段共聚物。这种工艺的主要优点是减少了每个阶段的单一过程，优化了反应时间和化学计量关系。
• EPSILON CAPROLACTAM COMPOSITIONS AND BYPRODUCTS
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0975590A1

  公开（公告）日：2000-02-02
• QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS
  申请人：Amgen Inc.

  公开号：EP1478645A2

  公开（公告）日：2004-11-24
• SCALE-UP PROCESS OF BIFUNCTIONALIZED TRIBLOCK COPOLYMERS WITH SECONDARY AND TERTIARY AMINES, WITH APPLICATION IN DEWATERING AND DESALTING OF HEAVY CRUDE OILS
  申请人：INSTITUTO MEXICANO DEL PETROLEO

  公开号：US20140364566A1

  公开（公告）日：2014-12-11

  A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POE w -POP y -POE w ) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.