N,N-di(acridin-9-yl)hexane-1,6-diamine | 58903-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N-di(acridin-9-yl)hexane-1,6-diamine
• 英文别名: 1,6-Di-(9-aminoacridinyl)hexane；N,N'-Di(9-acridyl)-1,6-diaminohexan；N,N'-Bis(9-acridinyl)-1,6-hexanediamine；N,N'-di(acridin-9-yl)hexane-1,6-diamine
• CAS: 58903-52-9
• 化学式: C₃₂H₃₀N₄
• 分子量: 470.617
• InChiKey: FZSBSJDISGQMLW-UHFFFAOYSA-N

物化性质

• 沸点：
  732.3±55.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  9-异硫氰酸酯吖啶 在 三乙胺 、 mercury dichloride 作用下， 以 甲苯 为溶剂， 生成 N,N-di(acridin-9-yl)hexane-1,6-diamine
  参考文献：
  名称：

  9-A啶基胍。通过聚亚甲基接头连接的胍的单，双，三和四-9 ac啶基衍生物

  摘要：

  9-异硫氰酸根合r啶被转化为containing啶的9-胍基衍生物，其包含一个，两个，三个或四个通过可变长度的多亚甲基接头分开的9-氨基ac啶基。

  DOI：

  10.1039/c39830001015

文献信息

• Method for silver staining proteins and nucleic acids
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0175371A2

  公开（公告）日：1986-03-26

  A method is disclosed for the optical detection of proteins and nucleic acids in a matrix, such as plyacrylamide electrophoresis gels. The method comprises fixing the proteins and nucleic acids in the matrix using aromatic sulfonic acids having tertiary amines capable of forming condination complexes with silver ion.

  本发明公开了一种对聚丙烯酰胺电泳凝胶等基质中的蛋白质和核酸进行光学检测的方法。 该方法包括使用具有能与银离子形成缩合络合物的叔胺的芳香族磺酸将蛋白质和核酸固定在基质中。
• Materials for enhancing staining of biopolymers in matrices
  申请人：Invitrogen Corporation

  公开号：US20020137222A1

  公开（公告）日：2002-09-26

  Disclosed is a method for detecting biopolymers in a matrix. More specifically, the invention involves (a) contacting the matrix with a sensitizing reagent comprising one or more optionally substituted heteroaromatic compounds; (b) contacting the matrix with one or more reduceable metal salts to stain said biopolymer; and (c) detecting the stained biopolymer. The invention also relates to compositions for carrying out the invention and compositions made according to the invention. The invention also relates to kits for carrying out the methods of the invention.

  本发明公开了一种检测基质中生物聚合物的方法。更具体地说，本发明包括 (a) 将基质与由一种或多种任选取代的杂芳香族化合物组成的敏化试剂接触； (b) 将基质与一种或多种可还原金属盐接触，对所述生物聚合物进行染色；以及 (c) 检测被染色的生物聚合物。 本发明还涉及用于实施本发明的组合物和根据本发明制成的组合物。本发明还涉及用于实施本发明方法的试剂盒。
• Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity
  作者：William A. Denny、Graham J. Atwell、Bruce C. Baguley、Laurence P. G. Wakelin

  DOI：10.1021/jm00149a005

  日期：1985.11

  Four classes of diacridines, joined at the 9-position by linker chains of varying length, rigidity, and polarity, were evaluated for DNA-binding properties and antitumor activity. Diacridines linked by flexible chains of varying polarity show relatively fast chromophore exchange kinetics among DNA binding sites but slower dissociation rates, suggesting the potential for considerable "creeping" of the drug along the helix, and are inactive in vivo. The exchange kinetics can be slowed dramatically by inclusion of positive charges in the side chain, but the resulting polycationic drugs are inactive in vivo, possibly due to poor distribution. Diacridines linked by a rigid, polar but neutral dicarbamoylpyrazole chain retain slow exchange kinetics, have a greatly reduced potential "creep rate", and possess good in vitro potency and significant in vivo antileukemic activity.
• HANSEN, J. B.;THOMSEN, T.;BUCHRDT, O., J. CHEM. SOC. CHEM. COMMUN., 1983, N 18, 1015-1016
  作者：HANSEN, J. B.、THOMSEN, T.、BUCHRDT, O.

  DOI：——

  日期：——
• DENNY, W. A.;ATWELL, G. J.;BAGULEY, B. C.;WAKALIN, L. P. G., J. MED. CHEM., 1985, 28, N 11, 1568-1574
  作者：DENNY, W. A.、ATWELL, G. J.、BAGULEY, B. C.、WAKALIN, L. P. G.

  DOI：——

  日期：——