2-Hydroxy-2-(1-hydroxy-2-oxo-2-thiophen-2-ylethoxy)-1-thiophen-2-ylethanone | 1338052-11-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Hydroxy-2-(1-hydroxy-2-oxo-2-thiophen-2-ylethoxy)-1-thiophen-2-ylethanone
• 英文别名: 2-hydroxy-2-(1-hydroxy-2-oxo-2-thiophen-2-ylethoxy)-1-thiophen-2-ylethanone
• CAS: 1338052-11-1
• 化学式: C₁₂H₁₀O₅S₂
• 分子量: 298.34
• InChiKey: YELKVLYPTIGJLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-乙酰基噻吩 在 (Z/E)-2-bromo-2-[4-oxothiazolidin-2-ylidene]-N-phenylacetamide 、 二甲基亚砜 作用下， 反应 27.0h， 以43%的产率得到2-Hydroxy-2-(1-hydroxy-2-oxo-2-thiophen-2-ylethoxy)-1-thiophen-2-ylethanone
  参考文献：
  名称：

  Catalytic oxidations of enolizable ketones using 2-alkylidene-4-oxothiazolidine vinyl bromide

  摘要：

  Direct oxidation of enolizable ketones to alpha-hydroxy derivatives, vicinal dicarbonyls or tricarbonyl compounds has been achieved by a catalytic amount of 2-alkylidene-4-oxothiazolidine vinyl bromide in DMSO as a solvent. The yields range from moderate to good. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.08.022

文献信息

• Catalytic oxidations of enolizable ketones using 2-alkylidene-4-oxothiazolidine vinyl bromide
  作者：Marija Baranac-Stojanović、Rade Marković、Milovan Stojanović

  DOI：10.1016/j.tet.2011.08.022

  日期：2011.10

  Direct oxidation of enolizable ketones to alpha-hydroxy derivatives, vicinal dicarbonyls or tricarbonyl compounds has been achieved by a catalytic amount of 2-alkylidene-4-oxothiazolidine vinyl bromide in DMSO as a solvent. The yields range from moderate to good. (C) 2011 Elsevier Ltd. All rights reserved.