(2-(4-chloro-phenyl)-3-nitro-chroman-4-yl)-acetaldehyde | 1134455-47-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2-(4-chloro-phenyl)-3-nitro-chroman-4-yl)-acetaldehyde
• 英文别名: 2-[(2S,3R,4S)-2-(4-chlorophenyl)-3-nitro-3,4-dihydro-2H-chromen-4-yl]acetaldehyde
• CAS: 1134455-47-2
• 化学式: C₁₇H₁₄ClNO₄
• 分子量: 331.755
• InChiKey: VQTBZGYYVDPLNF-UAGQMJEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-(4-chloro-phenyl)-3-nitro-chroman-4-yl)-acetaldehyde 在 sodium chlorite 、 potassium dihydrogenphosphate 、 双氧水 作用下， 生成
  参考文献：
  名称：

  Catalytic Asymmetric oxa-Michael−Michael Cascade for Facile Construction of Chiral Chromans via an Aminal Intermediate

  摘要：

  An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.

  DOI：

  10.1021/ol9003433
• 作为产物：
  描述：

  3-(2-羟基苯基)-2-丙烯醛 、 1-(4-氯苯基)-2-硝基乙烯 在 (2S)-2-[二苯基[(三甲基硅酯)氧基]甲基]-吡咯烷 、 sodium acetate 作用下， 以 氯仿 为溶剂， 反应 12.0h， 生成 (2-(4-chloro-phenyl)-3-nitro-chroman-4-yl)-acetaldehyde 、 (2-(4-chloro-phenyl)-3-nitro-chroman-4-yl)-acetaldehyde
  参考文献：
  名称：

  Catalytic Asymmetric oxa-Michael−Michael Cascade for Facile Construction of Chiral Chromans via an Aminal Intermediate

  摘要：

  An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.

  DOI：

  10.1021/ol9003433

文献信息

• Catalytic Asymmetric oxa-Michael−Michael Cascade for Facile Construction of Chiral Chromans via an Aminal Intermediate
  作者：Liansuo Zu、Shilei Zhang、Hexin Xie、Wei Wang

  DOI：10.1021/ol9003433

  日期：2009.4.2

  An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.