N'-(10H-indolo[3,2-b]-quinolin-11-yl)-N,N-dimethyl-ethane-1,2-diamine | 188630-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N'-(10H-indolo[3,2-b]-quinolin-11-yl)-N,N-dimethyl-ethane-1,2-diamine
• 英文别名: SYUIQ-05；SYUIQ-5；11-(3-N,N-dimethylaminopropyl)amino-10H-indolo[3,2-b]quinoline；N-(10H-indolo[3,2-b]quinolin-11-yl)-N',N'-dimethylpropane-1,3-diamine
• CAS: 188630-47-9
• 化学式: C₂₀H₂₂N₄
• 分子量: 318.421
• InChiKey: CTDCVGDSVHUYMA-UHFFFAOYSA-N

物化性质

• 熔点：
  197-199 °C
• 沸点：
  564.2±45.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜：≥20mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  11-chloro-10H-indolo[3,2-b]quinoline 、 N,N-二甲基-1,3-二氨基丙烷 反应 24.0h， 以100%的产率得到N'-(10H-indolo[3,2-b]-quinolin-11-yl)-N,N-dimethyl-ethane-1,2-diamine
  参考文献：
  名称：

  稠合喹啉衍生物的合成及其抗肿瘤活性。IV。新型的11-氨基吲哚并[3,2-b]喹啉。

  摘要：

  制备具有多种胺部分的吲哚并[3,2-b]喹啉衍生物（1），并评估了其对小鼠P388白血病的抗肿瘤活性，目的是了解胺部分在抗肿瘤活性和抗肿瘤作用中的作用。寻找有效的胺部分。在苯基与氨基或甲磺酰胺基之间引入亚甲基导致活性降低或丧失。

  DOI：

  10.1248/cpb.45.406

文献信息

• Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo(3,2-b)quinolines.
  作者：Yasuo TAKEUCHI、Toshiaki ODA、Ming-rong CHANG、Yoko OKAMOTO、Junko ONO、Yoko ODA、Kyoko HARADA、Kuniko HASHIGAKI、Masatoshi YAMATO

  DOI：10.1248/cpb.45.406

  日期：——

  Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted

  制备具有多种胺部分的吲哚并[3,2-b]喹啉衍生物（1），并评估了其对小鼠P388白血病的抗肿瘤活性，目的是了解胺部分在抗肿瘤活性和抗肿瘤作用中的作用。寻找有效的胺部分。在苯基与氨基或甲磺酰胺基之间引入亚甲基导致活性降低或丧失。
• ELECTROCHEMICAL ARTICLE AND PROCESSES FOR MAKING SAME AND MAKING ELECTROCHEMICAL MEASUREMENTS
  申请人：SINTIM HERMAN O.

  公开号：US20150226689A1

  公开（公告）日：2015-08-13

  An electrochemical article includes: a substrate; a working electrode disposed on the substrate to contact a composition that includes: a fluid; and an analyte to adsorb to the working electrode and comprising an electroactive moiety, the reference electrode being configured to receive a plurality of electrons from the electroactive moiety, to donate electrons to the electroactive moiety, or a combination thereof; a reference electrode disposed on the substrate to contact the fluid; a counter electrode disposed on the substrate to contact the fluid; a heater disposed on the substrate to heat the analyte adsorbed on the working electrode to a selected temperature; and an electrically insulating layer interposed between the heater and the working electrode, the electrochemical article being microfabricated. A process for process for performing electrochemistry includes: introducing a composition to the electrochemical article; and transferring a plurality of electrons between the working electrode and the electroactive moiety to perform electrochemistry.
• Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase
  作者：Jin-Lin Zhou、Yu-Jing Lu、Tian-Miao Ou、Jun-Min Zhou、Zhi-Shu Huang、Xiao-Feng Zhu、Cui-Juan Du、Xian-Zhang Bu、Lin Ma、Lian-Quan Gu、Yue-Ming Li、Albert Sun-Chi Chan

  DOI：10.1021/jm050041b

  日期：2005.11.1

  potent telomerase inhibitors. The interaction of the G-quadruplex of human telomere DNA with these newly designed molecules was examined via circular dichroism spectroscopy and electrophoretic mobility shift assay (EMSA). The selectivity between the quindoline derivative (4a) and G-quadruplex or duplex DNA was investigated by competition dialysis. These new compounds as inhibitors of telomerase were

  设计并合成了一系列新的喹啉衍生物（4a-j），以开发新型有效的端粒酶抑制剂。人类端粒DNA的G四联体与这些新设计的分子之间的相互作用通过圆二色光谱和电泳迁移率迁移分析（EMSA）进行了检查。通过竞争渗析研究了喹啉衍生物（4a）与G-四链体或双链体DNA之间的选择性。还通过利用改良的端粒酶重复扩增方案（TRAP）测定法研究了这些作为端粒酶抑制剂的新化合物。结果表明，在喹啉的C-11位置引入供电子基团（例如取代的氨基）可显着改善对端粒酶活性的抑制作用（（Tel）IC50> 138 microM，对喹啉具有抑制作用，喹啉衍生物4a-j的浓度为0.44-12.3 microM。喹啉衍生物不仅稳定了G-四链体结构，而且诱导了富含G的端粒重复DNA序列折叠成四链体。