β-D-Glucopyranosyl(1->3)2-acetamido-2-deoxy-α-D-galactopyranose (N-Acetylchandrosin) | 31718-87-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-D-Glucopyranosyl(1->3)2-acetamido-2-deoxy-α-D-galactopyranose (N-Acetylchandrosin)
• 英文别名: 3-O-β-D-Glucopyranosyl-2-acetamido-2-deoxy-α-D-galaktose；Glc(b1-3)a-GalNAc；N-[(2S,3R,4R,5R,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
• CAS: 31718-87-3
• 化学式: C₁₄H₂₅NO₁₁
• 分子量: 383.353
• InChiKey: HMQPEDMEOBLSQB-JJADVJHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  198
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-乙酰胺基-2-脱氧-D-半乳糖 、 对氟苯甲醇 在 Acholetin phosphorylase 作用下， 以 aq. phosphate buffer 为溶剂， 生成 β-D-Glucopyranosyl(1->3)2-acetamido-2-deoxy-α-D-galactopyranose (N-Acetylchandrosin)
  参考文献：
  名称：

  [EN] ACHOLETIN BIOPOLYMERS AND METHODS FOR ENZYMATIC SYNTHESIS
  [FR] BIOPOLYMÈRES D'ACHOLÉTINE ET PROCÉDÉS DE SYNTHÈSE ENZYMATIQUE

  摘要：

  Provided herein are β-1,3-linked biopolymers (acholetin polysaccharides). Furthermore, provided herein are enzymatic methods and systems for producing β-1,3-linked oligosaccharides and polysaccharides using β-1,3-N-acetylglucosaminide phosphorylase (Acholetin phosphorylase (AchP)). The AchP was sourced from the genome of the cell wall-less Mollicute bacterium, Acholeplasma laidlawii and was found to synthesize β-1,3-linked N-acetylglucosamine (GlcNAc) or N-acetylgalactosamine (GalNAc) oligomers using the donor, α-N-acetylglucosamine 1-phosphate (GlcNAc1-P) or N-acetylgalactosamine 1-phosphate (GalNAc1-P).

  公开号：

  WO2022256920A1

文献信息

• [EN] ACHOLETIN BIOPOLYMERS AND METHODS FOR ENZYMATIC SYNTHESIS<br/>[FR] BIOPOLYMÈRES D'ACHOLÉTINE ET PROCÉDÉS DE SYNTHÈSE ENZYMATIQUE
  申请人：[en]THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：WO2022256920A1

  公开（公告）日：2022-12-15

  Provided herein are β-1,3-linked biopolymers (acholetin polysaccharides). Furthermore, provided herein are enzymatic methods and systems for producing β-1,3-linked oligosaccharides and polysaccharides using β-1,3-N-acetylglucosaminide phosphorylase (Acholetin phosphorylase (AchP)). The AchP was sourced from the genome of the cell wall-less Mollicute bacterium, Acholeplasma laidlawii and was found to synthesize β-1,3-linked N-acetylglucosamine (GlcNAc) or N-acetylgalactosamine (GalNAc) oligomers using the donor, α-N-acetylglucosamine 1-phosphate (GlcNAc1-P) or N-acetylgalactosamine 1-phosphate (GalNAc1-P).