(10Z)-2,5,6,7,8,9-hexahydro-1H-cyclopenta[9]annulen-4-one | 136000-33-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (10Z)-2,5,6,7,8,9-hexahydro-1H-cyclopenta[9]annulen-4-one
• CAS: 136000-33-4
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: ODVUDXBNEKPJKQ-POHAHGRESA-N

物化性质

• 沸点：
  343.6±9.0 °C(predicted)
• 密度：
  1.02±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (10Z)-2,5,6,7,8,9-hexahydro-1H-cyclopenta[9]annulen-4-one 在 对甲苯磺酸 作用下， 生成 (Z)-(3R,3aS)-3-Phenylsulfanyl-2,3,3a,5,6,7,8,9-octahydro-1H-cyclopentacyclononen-4-one
  参考文献：
  名称：

  New easy access to cyclopentanoid structures

  摘要：

  We describe new easy synthesis of functionalized di and tricyclic cyclopentane containing derivatives. The stereochemistries of the ring junction are well defined. The starting material tricyclic methylene cyclobutanols are easily obtained on large scale from inexpensive substrates.

  DOI：

  10.1016/0040-4039(91)80691-x
• 作为产物：
  描述：

  (4aS,4bS,8aR,8bS)-4b-Methoxy-decahydro-biphenylen-1-one 在 对甲苯磺酰胺 作用下， 以 甲苯 为溶剂， 以75%的产率得到(10Z)-2,5,6,7,8,9-hexahydro-1H-cyclopenta[9]annulen-4-one
  参考文献：
  名称：

  New easy access to cyclopentanoid structures

  摘要：

  We describe new easy synthesis of functionalized di and tricyclic cyclopentane containing derivatives. The stereochemistries of the ring junction are well defined. The starting material tricyclic methylene cyclobutanols are easily obtained on large scale from inexpensive substrates.

  DOI：

  10.1016/0040-4039(91)80691-x

文献信息

• New Access to Prostanoids Like from Easy Avaliable Starting Materials
  作者：Nicolas Brosse、Brigitte Jamart-Grégoire、Paul Caubère

  DOI：10.1246/cl.1995.193

  日期：1995.3

  Methylene cyclobutanols resulting from one step elimination-additions were transformed into new prostanoid-like derivatives with potential biological activity.

  一步消除加成产生的亚甲基环丁醇被转化为具有潜在生物活性的新的类前列腺素衍生物。
• New easy access to cyclopentanoid structures
  作者：Brigitte Jamart-Grégoire、Nicolas Brosse、Sandra Ianelli、Mario Nardelli、Paul Caubère

  DOI：10.1016/0040-4039(91)80691-x

  日期：1991.6

  We describe new easy synthesis of functionalized di and tricyclic cyclopentane containing derivatives. The stereochemistries of the ring junction are well defined. The starting material tricyclic methylene cyclobutanols are easily obtained on large scale from inexpensive substrates.