(R)-(E)-2,6-dimethylhept-4-en-3-ol | 168399-36-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-(E)-2,6-dimethylhept-4-en-3-ol
• 英文别名: (E,3R)-2,6-dimethylhept-4-en-3-ol
• CAS: 168399-36-8
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: BDEWQLXPXANDJE-CYNONHLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-(E)-2,6-dimethylhept-4-en-3-ol 在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 4 A molecular sieve 、 D-(-)-酒石酸二异丙酯 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 (3R,5R)-2,6-dimethyl-4,5-epoxy-heptan-3-ol
  参考文献：
  名称：

  Asymmetric synthesis of (3R,5R)- and (3S,5S)-2,6-dimethylheptane-3,5-diol, useful C2 chiral auxiliaries

  摘要：

  (R,R)- and (S,S)-2,6-Dimethylheptane-3,5-diol, which are useful C-2 chiral auxiliaries, have been both synthesized in high optical purity from 2,6-dimethylheptane-3,5-dione, by using as key step a Sharpless kinetic resolution.

  DOI：

  10.1016/0957-4166(95)00071-v
• 作为产物：
  描述：

  (+/-)-(E)-2,6-dimethylhept-4-en-3-ol 生成 (R)-(E)-2,6-dimethylhept-4-en-3-ol
  参考文献：
  名称：

  Asymmetric synthesis of (3R,5R)- and (3S,5S)-2,6-dimethylheptane-3,5-diol, useful C2 chiral auxiliaries

  摘要：

  (R,R)- and (S,S)-2,6-Dimethylheptane-3,5-diol, which are useful C-2 chiral auxiliaries, have been both synthesized in high optical purity from 2,6-dimethylheptane-3,5-dione, by using as key step a Sharpless kinetic resolution.

  DOI：

  10.1016/0957-4166(95)00071-v

文献信息

• Asymmetric synthesis of (3R,5R)- and (3S,5S)-2,6-dimethylheptane-3,5-diol, useful C2 chiral auxiliaries
  作者：C. Jacoby、J.C. Braekman、D. Daloze

  DOI：10.1016/0957-4166(95)00071-v

  日期：1995.3

  (R,R)- and (S,S)-2,6-Dimethylheptane-3,5-diol, which are useful C-2 chiral auxiliaries, have been both synthesized in high optical purity from 2,6-dimethylheptane-3,5-dione, by using as key step a Sharpless kinetic resolution.