2-(3-methylbut-2-enyloxy)ethan-1-ol | 33756-78-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3-methylbut-2-enyloxy)ethan-1-ol
• 英文别名: 3-Methyl-crotyloxyethanol；2-(3-methyl-but-2-enyloxy)-ethanol；2-(3,3-dimethylallyloxy)-ethanol；2-(3-methylbut-2-enoxy)ethanol
• CAS: 33756-78-4
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: XBVCDTSQEQPMQL-UHFFFAOYSA-N

物化性质

• 沸点：
  198.0±15.0 °C(Predicted)
• 密度：
  0.920±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-methylbut-2-enyloxy)ethan-1-ol 在 草酰氯 、 盐酸羟胺 、 碳酸氢钠 、 二甲基亚砜 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 生成 (3-methylbut-2-enyloxy)acetaldehyde oxime
  参考文献：
  名称：

  Intramolecular Cycloaddition of O-tert-Butyldimethylsilyloximes in the Presence of BF₃·OEt₂

  摘要：

  Intramolecular cycloaddition of novel 1,3-dipoles, N-boranonitrones, was examined. Treatment of O-tert-butyldimethylsilyloximes 9-12 having olefin moieties with 2 equiv of BF3 center dot OEt2 generated N-boranonitrones, which underwent intramolecular cycloaddition to afford N-nonsubstituted cycloadducts 16 (and/or 18) after extractive workup. Despite the Lewis-acidic conditions, the olefin geometry of the substrates was retained in the cycloadducts in the present cycloaddition. The electronic nature of the N-boranonitrones appeared to be electrophilic. In the case of substrate 11c, having an electron-donating methyl group at an internal position of the olefin moiety, the cycloaddition gave the bridged cycloadduct 18b. The cycloaddition proceeded at relatively low temperature, and the diastereoselectivity was high.

  DOI：

  10.1021/jo051652e
• 作为产物：
  描述：

  Prenylaldehyde ethylene acetal 在 lithium aluminium tetrahydride 、 三氯化铝 作用下， 以 乙醚 为溶剂， 生成 2-(3-methylbut-2-enyloxy)ethan-1-ol
  参考文献：
  名称：

  杂原子取代的甲基基团和连接到 1,3-二氧戊环的 C-2 上的乙烯基基团 (CR2=CR-) 对 AlH2Cl、AlH3 或 LiAlH4 对 1,3-二氧戊环氢解的难易和方向的影响

  摘要：

  2-甲基-1,3-二氧戊环的甲基上的杂原子取代基阻碍了 2-取代的 1,3-二氧戊环的醚溶液的 AlH2Cl 的氢解速率。杂原子在降低氢解容易度方面的有效性是 H < S < O < Br < NR2。这种延迟被认为是由于杂原子的电负性和/或一些 AlH2Cl 与杂原子的配位引起的过渡态不稳定导致中间氧碳离子。AlH2Cl 或 AlH3 在室温下乙醚中将 2-乙烯基-或 2-[烷基（或芳基）取代的乙烯基]-1,3-二氧戊环还原为仅 β,γ-不饱和烷基 β-羟乙基醚，预期产物是氢阴离子加成到 C-2 1,3-二氧戊环。

  DOI：

  10.1139/v71-422

文献信息

• Tributyltin hydride-mediated radical cyclisation of aldehydes and unsaturated ketones: the synthesis of hydroxy tetrahydrofurans, chromanols and related compounds
  作者：David Bebbington、Jon Bentley、Paul A Nilsson、Andrew F Parsons

  DOI：10.1016/s0040-4039(00)01586-0

  日期：2000.11

  The tributyltin hydride-mediated cyclisation of unsaturated ethers bearing an aldehyde or α,β-unsaturated ketone group is reported. Cyclisation proceeds via addition of the tributyltin radical to the carbonyl double bond and the resultant O-stannyl ketyl can add intramolecularly to electron-rich double bonds to form hydroxy tetrahydrofurans, chromanols or related compounds.

  据报道，三丁基氢化锡介导的带有醛或α，β-不饱和酮基的不饱和醚的环化。环化反应是通过将三丁基锡自由基加到羰基双键上而进行的，所得的O-锡烷基缩酮可以分子内加至富电子双键上，形成羟基四氢呋喃，苯并二氢呋喃或相关化合物。
• Primary Anion–π Catalysis of Epoxide‐Opening Ether Cyclization into Rings of Different Sizes: Access to New Reactivity
  作者：Miguel Paraja、Stefan Matile

  DOI：10.1002/anie.202000579

  日期：2020.4.6

  a promise anion-π catalysis has been reluctant to live up to. Herein, we report non-trivial reactions that work with anion-π catalysis, but not with Brønsted acids, under comparable conditions. Namely, we show that the anion-π templated autocatalysis and epoxide opening with alcoholate-π interactions can provide access to unconventional ring chemistry. For smaller rings, anion-π catalysis affords anti-Baldwin

  阴离子-π催化的概念集中在芳族π表面上阴离子过渡态的稳定化。最近，我们证明了在芳香族π表面上环氧化物开放醚环化的发生。尽管反应是通过非常规机制进行的，但所得产物与常规布朗斯台德酸催化的产物相同，并且符合鲍德温选择性规则。然而，不同的机制最终应该导致新产品的出现，阴离子-π催化一直不愿实现。在本文中，我们报告了在可比条件下适用于阴离子-π催化而不适用于布朗斯台德酸的非平凡反应。即，我们证明了阴离子-π模板化的自催化和具有醇盐-π相互作用的环氧化物开环可以提供非常规环化学的途径。对于较小的环，阴离子-π催化作用可提供抗鲍德温氧杂环戊烷，2-氧杂双环[3.3.0]辛烷，以及通过甲基迁移使鲍德温氧杂环丁烷膨胀。对于较大的环，阴离子-π模板自催化被认为减轻了折叠的熵损失，从而使不利的反鲍德温环化成为氧杂环丁烷和氧杂环丁烷。
• Substituted piperidines useful for the treatment of allergic diseases
  申请人：Aventis Pharmaceuticals, Inc.

  公开号：US06329392B1

  公开（公告）日：2001-12-11

  The present invention relates to novel substituted piperidine derivatives of the formula stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.

  本发明涉及一种新型的取代哌啶衍生物，其化学式为其立体异构体和药学上可接受的盐，可用作组胺受体拮抗剂和速激肽受体拮抗剂。这类拮抗剂在治疗过敏性疾病中很有用，包括：季节性鼻炎、过敏性鼻炎和鼻窦炎。
• Polycarboxylic acid copolymer, production method and use thereof
  申请人：——

  公开号：US20020193547A1

  公开（公告）日：2002-12-19

  It is an object of the present invention to provide a polycarboxylic acid copolymer which improves the water reducing capacity and workability of cement compositions and the like and making them easier to handle when the fluidity and water reducing capacity are at the same levels, a method of producing the copolymer, and a cement additive and a cement composition comprising the copolymer. The present invention is further to provide a polycarboxylic acid copolymer and a cement additive which are capable of improving the strength and durability of hardening products of cement compositions, hence can advantageously be used in ultrahigh strength concrete. The present invention is still further to provide a method of producing polycarboxylic acid copolymers having high water reducing capacity, reducing the viscosity of cement compositions and improving the workability in applying cement. The present invention is directed to a polycarboxylic acid copolymer which is obtained by copolymerization of monomer components comprising a polyalkyleneimine unsaturated monomer (A1) and an unsaturated carboxylic acid monomer (B).

  本发明的目的是提供一种聚羧酸共聚物，该共聚物可以提高水减量和可操作性，并使其更易于处理，当流动性和水减量相同时，制备该共聚物的方法以及包括该共聚物的水泥添加剂和水泥组合物。本发明还提供了一种聚羧酸共聚物和水泥添加剂，它们能够提高水泥组合物的硬化产品的强度和耐久性，因此可以有利地用于超高强度混凝土。本发明还提供了一种制备具有高水减量能力的聚羧酸共聚物的方法，该方法可以减少水泥组合物的粘度并改善应用水泥的可操作性。本发明涉及一种聚羧酸共聚物，该共聚物通过共聚合包括聚烷基亚胺不饱和单体（A1）和不饱和羧酸单体（B）的单体组分而得到。
• MULTI-BRANCHED POLYALKYLENE GLYCOL POLYMER, METHOD FOR PRODUCING THE SAME, AND ADMIXTURE FOR CEMENT
  申请人：Sakamoto Noboru

  公开号：US20110160393A1

  公开（公告）日：2011-06-30

  The present invention provides a multi-branched polyalkylene glycol polymer useful for various applications, especially for an admixture for cement, a dispersant, admixture for cement, and cement composition each comprising the same, a thiol compound having a polyalkylene glycol chain useful for materials and the like of the polymer, and a method for easily and effectively producing the multi-branched polyalkylene glycol polymer and the thiol compound having a polyalkylene glycol chain at low cost. The multi-branched polymer comprises: a polyalkylene glycol chain; a residue of a compound having three or more active hydrogen atoms; and a polymer portion having a constitutional unit derived from a vinyl monomer component, one end of the polyalkylene glycol chain bonding to the residue, and a terminal oxygen atom of at least one of the other ends of the polyalkylene glycol chain bonding to a main chain end of the polymer portion directly or via an organic residue.

  本发明提供了一种多支链聚烷基醚聚合物，适用于各种应用，特别是水泥掺合剂、分散剂、水泥掺合剂和包含它们的水泥组合物，以及具有聚烷基醚链的巯基化合物，用于聚合物等材料，以及一种低成本、易于有效生产多支链聚烷基醚聚合物和具有聚烷基醚链的巯基化合物的方法。多支链聚合物包括：聚烷基醚链；具有三个或更多活性氢原子的化合物残基；以及具有从乙烯单体组分衍生的构成单元的聚合物部分，聚烷基醚链的一端与残基结合，聚烷基醚链的至少一个其他端的端氧原子直接或通过有机残基与聚合物部分的主链端结合。