4-Hydroxy-2,2-dimethyl-butyraldehyde | 74398-35-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Hydroxy-2,2-dimethyl-butyraldehyde
• 英文别名: 4-Hydroxy-2,2-dimethylbutanal
• CAS: 74398-35-9
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: YHMMFPKTSXQULG-UHFFFAOYSA-N

物化性质

• 沸点：
  196.9±23.0 °C(Predicted)
• 密度：
  0.948±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-2,2-dimethyl-butyraldehyde 在 4 Angstroem MS 、 三氧化硫吡啶 、 二甲基亚砜 、 三乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-[(E)-(1,1-Dimethyl-4-phenylsulfonylbut-3-enyl)]-1,3-dithiane
  参考文献：
  名称：

  Samarium(II)-mediated 4-exo trig ketyl-olefin cyclisation of unsaturated aldehydes. A general, stereoselective synthesis of functionalised cyclobutanols

  摘要：

  gamma,delta-Unsaturated aldehydes having a quaternary centre in either the a or beta-position, have been prepared from substituted gamma-butyrolactones and undergo efficient 4-exo-trig ketyl-olefin cyclisation on treatment with samarium(II) iodide to give functionalised cyclobutanols. In all cases cyclisation occurs with complete diastereocontrol to give anti-cyclobutanol products. In the cyclisation of substrate 4ab, significant stereochemical control is achieved at three contiguous chiral centres. Both unsaturated esters and vinyl sulfones have been employed as substrates in the reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00910-7
• 作为产物：
  描述：

  Alpha,Alpha-二甲基-γ-丁内酯 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 生成 4-Hydroxy-2,2-dimethyl-butyraldehyde
  参考文献：
  名称：

  Samarium(II)-mediated 4-exo trig ketyl-olefin cyclisation of unsaturated aldehydes. A general, stereoselective synthesis of functionalised cyclobutanols

  摘要：

  gamma,delta-Unsaturated aldehydes having a quaternary centre in either the a or beta-position, have been prepared from substituted gamma-butyrolactones and undergo efficient 4-exo-trig ketyl-olefin cyclisation on treatment with samarium(II) iodide to give functionalised cyclobutanols. In all cases cyclisation occurs with complete diastereocontrol to give anti-cyclobutanol products. In the cyclisation of substrate 4ab, significant stereochemical control is achieved at three contiguous chiral centres. Both unsaturated esters and vinyl sulfones have been employed as substrates in the reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00910-7

文献信息

• Rhodium/Phosphine catalysed selective hydroformylation of biorenewable olefins
  作者：Samadhan A. Jagtap、Bhalchandra M. Bhanage

  DOI：10.1002/aoc.4478

  日期：2018.9

  This work reports rhodium catalyzed selective hydroformylation of natural olefins like eugenol, estragole, anethole, prenol and isoprenol using biphenyl based Buchwald phosphine ligands (S‐Phos (L1), t‐Bu XPhos (L2), Ru‐Phos (L3), Johnphos (L4) and DavePhos (L5). Ru‐Phos (L3) ligand exhibited high impact on the hydroformylation of eugenol providing high selectivity (90%) of linear aldehyde as major product

  这项工作报告了铑使用联苯基的布赫瓦尔德膦配体（S-Phos（L 1），t- Bu XPhos（L 2），Ru-Phos（L 3）对铑进行的天然烯烃如丁子香酚，雌三醇，茴香脑，戊烯醇和异戊烯醇的选择性加氢甲酰化反应），Johnphos（L 4）和DavePhos（L 5）。Ru ‐Phos（L 3）配体对丁子香酚的加氢甲酰化表现出很高的影响，提供了线性醛作为主要产物的高选择性（90％）。此外，内部的天然烯烃（如茴香脑和早孕酚）提供了中等至高选择性的支链醛（分别为65％和85％）作为主要产物。研究了各种反应参数，例如配体的影响，P / Rh比，合成气压力，温度，时间和溶剂。生成线性醛的过程中获得较高的活性和选择性，可能是由于L 3膦配体中存在大体积的空间环己基和异丙氧基。而且，该催化体系在温和的反应条件下，能够以较高的选择性将天然烯烃平稳地转化为相应的直链和支链醛。
• Coloring composition, method for production thereof, and coloring method
  申请人：Nogami Atsushi

  公开号：US20100291359A1

  公开（公告）日：2010-11-18

  The present invention provides an image-recording/pixel-forming coloring composition containing a phthalocyanine type colorant having at least one group selected from alkyl and alkyloxy groups (alkylphthalocyanine type colorant). According to the present invention, there can also be provided a coloring composition containing a phthalocyanine type colorant capable of exhibiting excellent properties when used as an image-recording coloring composition or pixel-forming coloring composition, production processes of the phthalocyanine type colorants, a coloring method, and the like.

  本发明提供了一种含有至少一个从烷基和烷氧基中选择的基团的酞菁类着色剂（烷基酞菁类着色剂）的图像记录/像素形成着色组合物。根据本发明，还可以提供一种着色组合物，该组合物含有一种酞菁类着色剂，当用作图像记录着色组合物或像素形成着色组合物时，能够展现出优异的性能，以及酞菁类着色剂的生产工艺、着色方法等。
• COLORING COMPOSITION, METHOD FOR PRODUCTION THEREOF, AND COLORING METHOD
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP2206751A1

  公开（公告）日：2010-07-14

  The present invention provides an image-recording/pixel-forming coloring composition containing a phthalocyanine type colorant having at least one group selected from alkyl and alkyloxy groups (alkylphthalocyanine type colorant). According to the present invention, there can also be provided a coloring composition containing a phthalocyanine type colorant capable of exhibiting excellent properties when used as an image-recording coloring composition or pixel-forming coloring composition, production processes of the phthalocyanine type colorants, a coloring method, and the like.

  本发明提供了一种含有酞菁类着色剂的图像记录/像素形成着色组合物，该着色剂具有至少一个选自烷基和烷氧基的基团（烷基酞菁类着色剂）。根据本发明，还可以提供一种含有酞菁类着色剂的着色组合物，该着色组合物在用作图像记录着色组合物或像素形成着色组合物时能够表现出优异的性能，还可以提供酞菁类着色剂的生产工艺、着色方法等。
• PIXEL-FORMING COLORANT COMPOSITIONS AND THEIR USE
  申请人：Nogami Atsushi

  公开号：US20060213394A1

  公开（公告）日：2006-09-28

  A pixel-forming colorant composition contains at least one green colorant selected from the group consisting of the following pigments (A) and (B) and pigment derivative (C): (A) a copper phthalocyanine green pigment obtained by reacting at least one of a phthalic acid substituted on average with from 3.5 to 4.0 bromine atoms and a derivative thereof with a copper salt, substituted on average with from 14 to 16 bromine atoms, and substituted with no chlorine atom; (B) a copper phthalocyanine green pigment obtained by reacting a mixture, which comprises at least one of a phthalic acid having at least one bromine atom and a derivative thereof and at least one of a phthalic acid having at least one chlorine atom and a derivative thereof, with a copper salt, substituted on average with not less than 12 but less than 16 bromine atoms, and substituted on average with not more than 4 but more than 0 chlorine atom(s); and (C) a green pigment derivative obtained by introducing at least one substituent in at least one of the copper phthalocyanine green pigments (A) and (B). The pixel-forming colorant composition is useful for the formation of G pixels of three primary-color pixels on color filters.

  一种像素形成着色剂组合物含有至少一种绿色着色剂，该绿色着色剂选自由下列颜料（A）和（B）以及颜料衍生物（C）组成的组：（A）铜酞菁绿色颜料，该绿色颜料是由平均被 3.5 至 4.0 个溴原子的邻苯二甲酸及其衍生物中的至少一种与平均被 14 至 16 个溴原子取代且未被氯原子取代的铜盐反应而得到的铜酞菁绿颜料；(B) 一种铜酞菁绿色颜料，由至少一种具有至少一个溴原子的邻苯二甲酸及其衍生物和至少一种具有至少一个氯原子的邻苯二甲酸及其衍生物的混合物与一种平均被不少于 12 个但少于 16 个溴原子取代且平均被不多于 4 个但多于 0 个氯原子取代的铜盐反应而得；(C) 通过在铜酞菁绿色颜料（A）和（B）中的至少一种中引入至少一个取代基而得到的绿色颜料衍生物。像素形成着色剂组合物适用于在彩色滤光片上形成三原色像素的 G 像素。
• Pixel-forming colorant compositions and their use
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP1717277B1

  公开（公告）日：2012-01-04