2-甲氧基-1-(2-甲氧基丙氧基)丙烷 | 63019-84-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-甲氧基-1-(2-甲氧基丙氧基)丙烷
• 英文名称: 2-methoxypropyl ether
• 英文别名: Propane, 1,1'-oxybis(2-methoxy-；2-methoxy-1-(2-methoxypropoxy)propane
• CAS: 63019-84-1
• 化学式: C₈H₁₈O₃
• 分子量: 162.229
• InChiKey: LQJWWOYBOHBPLG-UHFFFAOYSA-N

物化性质

• 沸点：
  178.8±15.0 °C(Predicted)
• 密度：
  0.899±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙二醇甲醚 、 (2S)-2-甲氧基-1-丙醇 生成 dipropylene glycol dimethyl ether 、 二丙烯乙二醇二甲基醚 、 2-甲氧基-1-(2-甲氧基丙氧基)丙烷
  参考文献：
  名称：

  聚（环氧丙烷）二聚模型化合物的碳 13 NMR 化学位移：(C-H)···O 吸引力存在的证明

  摘要：

  聚 (环氧丙烷) (PPO) 的构象能已由其六种二聚模型化合物的 13C NMR 化学位移确定。模型化合物的制备和超临界流体色谱分离成三个组分：CH3OCH2CH(CH3)OCH2CH(CH3)OCH3（头对尾）；CH3OCH2CH(CH3)OCH(CH3)CH2OCH3（头对头）；CH3OCH(CH3)CH2OCH2CH(CH3)OCH3（尾对尾）。使用 1H 宽带去耦和 DEPT 技术对苯溶液在 25 °C 下进行碳 13 NMR 测量，所有观察到的 NMR 峰都归属于次甲基、亚甲基、侧甲基和末端甲氧基碳。通过基于旋转异构态（RIS）方案和13C NMR化学位移的γ-和δ-取代基效应的模拟，优化了γ-和δ-效应参数和构象能；计算和观察到的化学位移之间的均方根误差最小化为 0.12 ppm。氧气的 γ-抗效应 (-2.6 ppm)、γ-gauche ...

  DOI：

  10.1021/jp002923m

文献信息

• [EN] PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRAZOLYLBENZO[D]IMIDAZOLE
  申请人：CELON PHARMA SA

  公开号：WO2014141015A1

  公开（公告）日：2014-09-18

  A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents –CH2-, –C(O)-, or –C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight-or branched-chain C1-C3 alkyl, –(CH2)l-NR2R3, or–(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent;and R2and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6- membered saturated heterocyclicring, wherein one of carbon atoms can be replaced with oxygen, -NH-or –N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)

  化合物的一般公式（I）表示，其中作为连接到吡唑和苯并咪唑环的氢原子分别连接到吡唑或苯并咪唑环的氮原子之一；R1表示-X-Q-P，其中X不存在或表示-CH2-，-C(O)-或-C(O)NH-( )k-，其中k为0、1或2；Q从Q1、Q2、Q3、Q4和Q5组成的群体中选择；P不存在或表示直链或支链C1-C3烷基，-( )l-NR2R3，或-( )m-C(O)-NR2R3，其中l和m独立地表示0、1或2，但当Q1中的B表示氧原子时，P不存在；R2和R3独立地表示C1或C2烷基，或R2和R3与它们都连接的氮原子一起形成一个6-成员饱和杂环，其中一个碳原子可以被氧、-NH-或-N(C1-C2)烷基取代；以及其酸盐。该化合物可用于治疗癌症疾病。（I）
• [EN] METHOD FOR PREPARING ETHERS OF CYCLOALIPHATIC OR ARALIPHATIC DIOLS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ÉTHERS DE DIOLS CYCLOALIPHATIQUES OU ARALIPHATIQUES
  申请人：BASF SE

  公开号：WO2019110464A1

  公开（公告）日：2019-06-13

  The present invention relates to a method for preparing a dialkyi or dialkenyl ether of a cycloaliphatic or araliphatic diol, which comprises (i) reacting the cycloaliphatic or araliphatic diol with metallic sodium in an aprotic organic solvent in the presence of a catalytic amount of at least one monoether- monoalcohol of formula (I) wherein Y is identical or different and selected from C2-C4-alkylene, n is an integer in the range from 1 to 10, and R1 is C1-C4-Alkyl, whereby the corresponding disodium dialcoholate is obtained, reacting the disodium dialcoholate obtained in step (i) with an alkylation alkenylation reagent.

  本发明涉及一种制备环脂环烷基或芳基二醇的二烷氧基或二烯氧基醚的方法，包括（i）在无水无氢的有机溶剂中，在至少一种式（I）的单醚-单醇的催化量存在下，将环脂环烷基或芳基二醇与金属钠反应，其中式中Y相同或不同，选择自C2-C4-烷基，n是1到10之间的整数，R1是C1-C4-烷基，从而得到相应的二钠二醇酸盐，将步骤（i）中得到的二钠二醇酸盐与烷基化烯基化试剂反应。
• PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES
  申请人：CELON PHARMA S.A.

  公开号：US20160039794A1

  公开（公告）日：2016-02-11

  A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R 1 represents —X-Q-P, wherein X is absent or represents —CH 2 —, —C(O)—, or —C(O)NH—(CH 2 ) k —, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight- or branched-chain C1-C3 alkyl, —(CH 2 ) l —NR 2 R 3 , or —(CH 2 ) m —C(O)—NR 2 R 3 , wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent; and R 2 and R 3 independently represent C1 or C2 alkyl, or R 2 and R 3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, —NH—or —N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)

  化合物的通式（I）表示，其中连接到吡唑和苯并咪唑环的氢原子分别连接到吡唑或苯并咪唑环的一个氮原子上；R1表示-X-Q-P，其中X不存在或表示-CH2-，-C（O）-或-C（O）NH-（ ）k-，其中k为0、1或2；Q从Q1、Q2、Q3、Q4和Q5组成的群体中选择；P不存在或表示直链或支链C1-C3烷基，-（ ）l-NR2R3或-（ ）m-C（O）-NR2R3，其中l和m独立地表示0、1或2，但是当Q1中的B表示氧原子时，P不存在；R2和R3独立地表示C1或C2烷基，或者R2和R3与它们都连接的氮原子一起形成一个6元饱和杂环，其中一个碳原子可以被氧、-NH-或-N（C1-C2）烷基取代；以及它的酸加成盐。该化合物可用于治疗癌症。
• Method for preparing ethers of cycloaliphatic or araliphatic diols
  申请人：BASF SE

  公开号：US11078146B2

  公开（公告）日：2021-08-03

  The present invention relates to a method for preparing a dialkyi or dialkenyl ether of a cycloaliphatic or araliphatic diol, which comprises (i) reacting the cycloaliphatic or araliphatic diol with metallic sodium in an aprotic organic solvent in the presence of a catalytic amount of at least one monoether-monoalcohol of formula (I) wherein Y is identical or different and selected from C2-C4-alkylene, n is an integer in the range from 1 to 10, and R1 is C1-C4-Alkyl, whereby the corresponding disodium dialcoholate is obtained, reacting the disodium dialcoholate obtained in step (i) with an alkylation alkenylation reagent.

  本发明涉及一种制备环脂族或脂肪族二元醇的二酮基或二烯基醚的方法，其包括 (i) 在催化量的至少一种式(I)的单醚一元醇存在下，在非沸腾有机溶剂中使环脂族或脂肪族二元醇与金属钠反应，式(I)中Y为相同或不同且选自C2-C4-烯烃、n 为 1-10 之间的整数，R1 为 C1-C4 烷基，将步骤(i)中得到的二醇二钠与烷基化烯基化试剂反应，可得到相应的二醇二钠。
• Ink composition and method for use thereof in the manufacturing of electrochemical sensors
  申请人：Davies Oliver William Hardwicke

  公开号：US20050096409A1

  公开（公告）日：2005-05-05

  An ink composition for manufacturing electrochemical sensors in accordance with the present invention includes graphite, carbon black, a resin and at least one solvent (e.g., at least one solvent with a boiling point between 120° C. and 250° C.). The ink composition has a weight ratio of graphite to carbon black is in a range of from 4:1 to 1:4 and a weight ratio of a sum of graphite and carbon black to resin in a range of from 10:1 to 1:1. Also, a method for manufacturing an electrochemical sensor includes transporting a substrate web past at least one print station and printing at least one electrochemical sensor electrode on the substrate web at the print station(s). The printing is accomplished by applying an ink composition to substrate web, wherein the ink composition includes, graphite, carbon black, a resin and at least one solvent. In addition, weight ratio of graphite to carbon black in the ink composition is in a range of from 4:1 to 1:4 and a weight ratio of a sum of graphite and carbon black to resin is in a range of from 10:1 to 1:1.

  根据本发明，一种用于制造电化学传感器的油墨组合物包括石墨、炭黑、树脂和至少一种溶剂（例如，沸点在120℃至250℃之间的至少一种溶剂）。油墨组合物中石墨与炭黑的重量比在 4:1 至 1:4 之间，石墨与炭黑之和与树脂的重量比在 10:1 至 1:1 之间。另外，一种制造电化学传感器的方法包括将基材卷经过至少一个打印站，并在打印站将至少一个电化学传感器电极打印在基材卷上。印刷是通过将油墨组合物涂在基材卷材上完成的，其中油墨组合物包括石墨、炭黑、树脂和至少一种溶剂。此外，油墨组合物中石墨与炭黑的重量比在 4:1 至 1:4 之间，石墨与炭黑之和与树脂的重量比在 10:1 至 1:1 之间。