azulen-1-yl-methanol | 72220-30-5

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: azulen-1-yl-methanol
• 英文别名: 1-Azylen-methyl-ol；Hydroxymethylazulene；azulen-1-ylmethanol
• CAS: 72220-30-5
• 化学式: C₁₁H₁₀O
• 分子量: 158.2
• InChiKey: JWCLLPIFLOXQEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  奥苷菊环 在 lithium aluminium tetrahydride 、 乙醚 、 N,N-二甲基甲酰胺 、 三氯氧磷 作用下， 生成 azulen-1-yl-methanol
  参考文献：
  名称：

  Hafner; Bernhard, Justus Liebigs Annalen der Chemie, 1959, vol. 625, p. 108,122

  摘要：

  DOI：

文献信息

• METHOD OF PRODUCING OPTICALLY ACTIVE ALCOHOL
  申请人：Kotobuki Pharmaceutical Co., Ltd.

  公开号：EP1988071A1

  公开（公告）日：2008-11-05

  This invention relates to a process for producing optically active alcohols using asymmetric reduction of aromatic ketones. This process gives optically active alcohols in high enantioselectivity at large scale production. Aromatic ketones represented by formula (I) [wherein, R1 are selected from hydrogen atom, halogen atom, lower alkyl group etc. R2 is -(CH2)n-R3 [wherein, n is 1 to 5 integer. R3 are selected from hydrogen atom, halogen atom, lower alkoxycarbonyl group etc. and formula (II) and (III). wherein, R4 is selected from lower alkyl group (1 to 5 carbon atom) etc. R5 and R6 are the same or different and are selected from hydrogen atom, halogen atom, lower alkyl group etc.}]] are reduced by sodium borohydride, chlorotrimethylsilane and optically active 2-[bis(4-methoxyphenyl)hydroxymethyl]pyrrolidine represented by formula (IV) to give optically active alcohol represented by formula (V) stereoselectively. (wherein, R1 and R2 are as defined above.)

  本发明涉及一种利用芳香酮的不对称还原生产光学活性醇的工艺。该工艺可大规模生产高对映选择性的光学活性醇。式 (I) 所代表的芳香酮 [其中，R1 选自氢原子、卤素原子、低级烷基等。R2 是-(CH2)n-R3[其中，n 是 1 至 5 的整数。R3 选自氢原子、卤素原子、低级烷氧羰基等以及式 (II) 和 (III)。 其中，R4 选自低级烷基（1 至 5 个碳原子）等。R5 和 R6 相同或不同，选自氢原子、卤素原子、低级烷基等}]]通过硼氢化钠、氯三甲基硅烷和光学活性 2-[双（4-甲氧基苯基）羟甲基]吡咯烷还原，由式（IV）代表 立体选择性地得到由式 (V) 代表的光学活性醇。 (其中，R1 和 R2 如上定义）。
• Treibs, Chemische Berichte, 1959, vol. 92, p. 2152,2159
  作者：Treibs

  DOI：——

  日期：——
• Process for Preparing Optically Active Alcohols
  申请人：Tomiyama Hiroshi

  公开号：US20090062527A1

  公开（公告）日：2009-03-05

  This invention relates to a process for producing optically active alcohols using asymmetric reduction of aromatic ketones. This process gives optically active alcohols in high enantioselectivity at large scale production. Aromatic ketones represented by formula (I) [wherein, R 1 are selected from hydrogen atom, halogen atom, lower alkyl group etc. R 2 is —(CH 2 )n-R 3 [wherein, n is 1 to 5 integer. R 3 are selected from hydrogen atom, halogen atom, lower alkoxycarbonyl group etc. and formula (II) and (III). wherein, R 4 is selected from lower alkyl group (1 to 5 carbon atom) etc. R 5 and R 6 are the same or different and are selected from hydrogen atom, halogen atom, lower alkyl group etc.}]] are reduced by sodium borohydride, chlorotrimethylsilane and optically active 2-[bis(4-methoxyphenyl)hydroxymethyl]pyrrolidine represented by formula (IV) to give optically active alcohol represented by formula (V) stereoselectively. (wherein, R 1 and R 2 are as defined above.)
• Fragrance Compositions
  申请人：The Procter & Gamble Company

  公开号：US20150164764A1

  公开（公告）日：2015-06-18

  A fragrance composition having improved intensity and/or longevity of the fragrance profile, including less than about 30 wt % of low volatile fragrance materials (i.e., base notes) having a vapor pressure less than 0.001 Torr at 25° C., and at least one non-odorous fragrance modulator form from an alkoxylated glucoside.
• US7956182B2
  申请人：——

  公开号：US7956182B2

  公开（公告）日：2011-06-07