4-[(2,5-Difluorophenyl)amino]-6,7-dimethoxyquinoline-3-carboxamide | 476192-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[(2,5-Difluorophenyl)amino]-6,7-dimethoxyquinoline-3-carboxamide
• 英文别名: 4-(2,5-Difluoroanilino)-6,7-dimethoxy-3-quinolinecarboxamide；4-(2,5-Difluorophenylamino)-6,7-dimethoxyquinoline-3-carboxamide；4-(2,5-difluoroanilino)-6,7-dimethoxyquinoline-3-carboxamide
• CAS: 476192-01-5
• 化学式: C₁₈H₁₅F₂N₃O₃
• 分子量: 359.332
• InChiKey: YMHNYVNOYXPQLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  86.5
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-chloro-6,7-dimethoxy-3-quinolinecarboxamide 、 2,5-二氟苯胺 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 4-[(2,5-Difluorophenyl)amino]-6,7-dimethoxyquinoline-3-carboxamide
  参考文献：
  名称：

  Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

  摘要：

  3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modi. cations at the quinoline 6- and 7-positions. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.046

文献信息

• Novel 4-anilinoquinoline-3-carboxamides
  申请人：——

  公开号：US20040248923A1

  公开（公告）日：2004-12-09

  The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.

  本发明涉及公式（IA）的新型化合物，它们是JAK3激酶抑制剂，以及它们的制备方法和包含它们的药物组合物。
• NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES
  申请人：AstraZeneca AB

  公开号：EP1387830A1

  公开（公告）日：2004-02-11
• US7037925B2
  申请人：——

  公开号：US7037925B2

  公开（公告）日：2006-05-02
• [EN] NOVEL 4-ANILINOQUINOLINE-3-CARBOXAMIDES<br/>[FR] NOUVEAUX 4-ANILINOQUINOLINE-3-CARBOXAMIDES
  申请人：ASTRAZENECA AB

  公开号：WO2002092571A1

  公开（公告）日：2002-11-21

  The present invention relates to novel compounds of formula (IA), which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them.
• Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase
  作者：David A. Scott、Carrie L. Balliet、Donald J. Cook、Audrey M. Davies、Thomas W. Gero、Charles A. Omer、Srinivasu Poondru、Maria-Elena Theoclitou、Boris Tyurin、Michael J. Zinda

  DOI：10.1016/j.bmcl.2008.12.046

  日期：2009.2

  3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modi. cations at the quinoline 6- and 7-positions. (c) 2008 Elsevier Ltd. All rights reserved.