1-isopropylsulfanyl-3,3-dimethyl-butan-2-one | 39199-15-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-isopropylsulfanyl-3,3-dimethyl-butan-2-one
• 英文别名: 3,3-Dimethyl-1-propan-2-ylsulfanylbutan-2-one
• CAS: 39199-15-0
• 化学式: C₉H₁₈OS
• 分子量: 174.307
• InChiKey: WQNIBNRNDXLQPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(1-Chloro-3,3-dimethyl-2-butylidene)isopropylamine 在 草酸 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 3.5h， 生成 1-isopropylsulfanyl-3,3-dimethyl-butan-2-one
  参考文献：
  名称：

  α-卤代甲基酮亚胺的合成与反应性

  摘要：

  首次描述了N-（1-卤-2-亚烷基）胺，即α-卤甲基酮亚胺的合成，利用TiCl 4诱导的α-卤甲基酮与伯胺的缩合反应。研究了这些新的α-卤代甲基酮亚胺对亲核试剂（如碘化物，氰化物，醇，醇盐，胺和硫醇盐）的反应性。α-卤甲基酮亚胺是强大的环境亲电体，它经历了各种反应，导致官能化的亚胺和杂环。

  DOI：

  10.1016/s0040-4020(01)88533-1

文献信息

• AMATOXIN DERIVATIVES AND CELL-PERMEABLE CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
  申请人：MENDELSOHN Brian Alan

  公开号：US20150218220A1

  公开（公告）日：2015-08-06

  The present invention relates to analogs of alpha-amanitin, methods of inhibiting RNA polymerase with such compounds, conjugates comprising such compounds, compositions comprising such compounds and conjugates, and methods of treatment using such conjugates.
• COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD117+ CELLS
  申请人：Magenta Therapeutics, Inc.

  公开号：US20170360954A1

  公开（公告）日：2017-12-21

  The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, ligands, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
• CARBOHYDRATE LIGANDS THAT BIND TO IGM ANTIBODIES AGAINST MYELIN-ASSOCIATED GLYCOPROTEIN
  申请人：UNIVERSITÄT BASEL

  公开号：US20220185838A1

  公开（公告）日：2022-06-16

  The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.
• US9994605B2
  申请人：——

  公开号：US9994605B2

  公开（公告）日：2018-06-12
• Synthesis and reactivity of α-halomethyl ketimines
  作者：Norbert de Kimpe、Wim de Cock、Christian Stevens

  DOI：10.1016/s0040-4020(01)88533-1

  日期：1992.3

  N-(1-halo-2-alkylidene)amines, i.e. α-halomethyl ketimines, is described for the first time, utilizing the TiCl4-induced condensation of α-halomethyl ketones with primary amines. The reactivity of these new α-halomethylketimines was studied with respect to nucleophiles such as iodide, cyanide, alcohols, alkoxides, amines and thiolates. α-Halomethyl ketimines are powerful ambident electrophiles which underwent

  首次描述了N-（1-卤-2-亚烷基）胺，即α-卤甲基酮亚胺的合成，利用TiCl 4诱导的α-卤甲基酮与伯胺的缩合反应。研究了这些新的α-卤代甲基酮亚胺对亲核试剂（如碘化物，氰化物，醇，醇盐，胺和硫醇盐）的反应性。α-卤甲基酮亚胺是强大的环境亲电体，它经历了各种反应，导致官能化的亚胺和杂环。