9-(3,4-dichlorophenyl)-7-methyl-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one | 1229706-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(3,4-dichlorophenyl)-7-methyl-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one
• CAS: 1229706-23-3
• 化学式: C₁₈H₁₃Cl₂NO₂
• 分子量: 346.213
• InChiKey: PDQTXMBXLROBPV-UHFFFAOYSA-N

物化性质

• 沸点：
  510.0±50.0 °C(predicted)
• 密度：
  1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-羟乙酰乙酸内酯 、 乙烷,三氯氟- 、 3,4-二氯苯甲醛 在 L-脯氨酸 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以93%的产率得到9-(3,4-dichlorophenyl)-7-methyl-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one
  参考文献：
  名称：

  Regioselective Synthesis and in Vitro Anticancer Activity of 4-Aza-podophyllotoxin Derivatives Catalyzed by l-Proline

  摘要：

  A series of 4-aza-podophyllotoxin derivatives have been synthesized regioselectively via the three-component reaction of aldehydes, aromatic amines, and tetronic acid catalyzed by L-proline. This method has the advantages of high yield, high regioselectivity, extensive adaptability, easy operation, and environmental friendliness. These compounds were also investigated in vitro, and sonic were found to have good anticancer activity.

  DOI：

  10.1021/cc100003c

文献信息

• Regioselective Synthesis and in Vitro Anticancer Activity of 4-Aza-podophyllotoxin Derivatives Catalyzed by <scp>l</scp>-Proline
  作者：Chunling Shi、Juxian Wang、Hui Chen、Daqing Shi

  DOI：10.1021/cc100003c

  日期：2010.7.12

  A series of 4-aza-podophyllotoxin derivatives have been synthesized regioselectively via the three-component reaction of aldehydes, aromatic amines, and tetronic acid catalyzed by L-proline. This method has the advantages of high yield, high regioselectivity, extensive adaptability, easy operation, and environmental friendliness. These compounds were also investigated in vitro, and sonic were found to have good anticancer activity.