6-(benzyloxy)-8-phenylquinoline | 1275591-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(benzyloxy)-8-phenylquinoline
• 英文别名: 8-Phenyl-6-phenylmethoxyquinoline；8-phenyl-6-phenylmethoxyquinoline
• CAS: 1275591-27-9
• 化学式: C₂₂H₁₇NO
• 分子量: 311.383
• InChiKey: RZLHRHQMNWFIQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  溴苯 、 6-(苄氧基)喹啉 在 dirhodium tetraacetate 、 1,3-双(2,4,6-三甲基苯基)氯化咪唑 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以90%的产率得到6-(benzyloxy)-8-phenylquinoline
  参考文献：
  名称：

  Rh(NHC)-Catalyzed Direct and Selective Arylation of Quinolines at the 8-Position

  摘要：

  A new catalytic protocol for the regioselective direct arylation of quinoline derivatives at the 8-position has been developed. The reaction is catalyzed by a Rh(NHC) system, and the choice of the NHC ligand was most important for achieving high reactivity and selectivity.

  DOI：

  10.1021/ja111670s

文献信息

• Rh(NHC)-Catalyzed Direct and Selective Arylation of Quinolines at the 8-Position
  作者：Jaesung Kwak、Min Kim、Sukbok Chang

  DOI：10.1021/ja111670s

  日期：2011.3.23

  A new catalytic protocol for the regioselective direct arylation of quinoline derivatives at the 8-position has been developed. The reaction is catalyzed by a Rh(NHC) system, and the choice of the NHC ligand was most important for achieving high reactivity and selectivity.