(Z)-N-(4,6-diphenylhex-3-en-5-ynyl)-4-methylbenzenesulfonamide | 1109231-97-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (Z)-N-(4,6-diphenylhex-3-en-5-ynyl)-4-methylbenzenesulfonamide
• 英文别名: N-[(Z)-4,6-diphenylhex-3-en-5-ynyl]-4-methylbenzenesulfonamide
• CAS: 1109231-97-1
• 化学式: C₂₅H₂₃NO₂S
• 分子量: 401.529
• InChiKey: INSKIFZKYISROV-ZMOGYAJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-cyclopropyl-1,3-diphenylprop-2-yn-1-ol 、 对甲苯磺酰胺 在 ytterbium(III) triflate 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以75%的产率得到(Z)-N-(4,6-diphenylhex-3-en-5-ynyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Ytterbium(III) Triflate-Catalyzed Amination of 1-Cyclopropylprop-2-yn-1-ols as an Expedient Route to Conjugated Enynes

  摘要：

  Ytterbium(III) triflate-catalyzed ring opening of substituted 1-cyclopropyl-2-propyn-1-ols with sulfonamides as an efficient synthetic route to conjugated enynes is described herein. The reaction was operationally straightforward and accomplished in moderate to good yields and recgioselective manner in all except one case under mild conditions.

  DOI：

  10.1021/jo8024626

文献信息

• Ytterbium(III) Triflate-Catalyzed Amination of 1-Cyclopropylprop-2-yn-1-ols as an Expedient Route to Conjugated Enynes
  作者：Weidong Rao、Xiaoxiang Zhang、Ella Min Ling Sze、Philip Wai Hong Chan

  DOI：10.1021/jo8024626

  日期：2009.2.20

  Ytterbium(III) triflate-catalyzed ring opening of substituted 1-cyclopropyl-2-propyn-1-ols with sulfonamides as an efficient synthetic route to conjugated enynes is described herein. The reaction was operationally straightforward and accomplished in moderate to good yields and recgioselective manner in all except one case under mild conditions.