1,2-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide | 1053257-54-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide
• 英文别名: 1,2-d ihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide；1,2-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide；nicotinamide riboside；nicotinamide ribose；1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2H-pyridine-3-carboxamide
• CAS: 1053257-54-7
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.258
• InChiKey: FDFGNPCJMCLJQU-TURQNECASA-N

物化性质

• 沸点：
  605.3±55.0 °C(Predicted)
• 密度：
  1.539±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N(trimethylsilyl)nicotinamide 在 sodium tetrahydroborate 、 sodium methylate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 1,2-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide
  参考文献：
  名称：

  Chemical and Biochemical Reactivity of the Reduced Forms of Nicotinamide Riboside

  摘要：

  DOI：

  10.1021/acschembio.0c00757

文献信息

• [EN] PROCESS FOR PREPARATION OF NICOTINAMIDE RIBOSIDE (NR) AND COSMETIC COMPOSITION COMPRISING (NR AND A PHOSPHATE-BINDING AGENT<br/>[FR] PROCÉDÉ DE PRÉPARATION DE NICOTINAMIDE RIBOSIDE (NR) ET COMPOSITION COSMÉTIQUE COMPRENANT DU NR ET UN AGENT DE LIAISON DE PHOSPHATE
  申请人：YISSUM RES DEV CO

  公开号：WO2017145151A1

  公开（公告）日：2017-08-31

  Disclosed herein is a process for preparing nicotinamide riboside (NR) from an NR precursor and a phosphate-binding agent in a solvent. The reaction-derived mixture comprising NR may be further used without further processing in a variety of products, particularly in a cosmetic product.

  本文披露了一种从NR前体和磷酸盐结合剂在溶剂中制备烟酰胺核糖苷（NR）的过程。包含NR的反应产物混合物可以直接用于各种产品，特别是化妆品产品，无需进一步处理。
• [EN] REDUCED NICOTINAMIDERIBOSIDES FOR TREATING OR PREVENTING KIDNEY DISEASE<br/>[FR] NICOTINAMIDE RIBOSIDES RÉDUITS POUR TRAITER OU PRÉVENIR UNE MALADIE RÉNALE
  申请人：NESTLE SA

  公开号：WO2020245187A1

  公开（公告）日：2020-12-10

  The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of kidney diseases and conditions. In one embodiment of the invention, said compounds and compositions of the invention improve kidney function by reducing formation of kidney cysts, reducing glomerule dilatation, reducing renal cell apoptosis and preventing increases in blood urea nitrogen. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat acute kidney injury (AKI), chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis, nephrotic syndrome, renal fibrosis and kidney cancer.

  本发明提供了含有还原型烟酰胺核苷酸的化合物和组合物，用于预防和/或治疗肾脏疾病和病况的方法。在本发明的一种实施例中，所述发明的化合物和组合物通过减少肾囊肿的形成、减少肾小球扩张、减少肾细胞凋亡和预防血尿素氮的增加来改善肾功能。在本发明的另一种实施例中，本发明的化合物和组合物可用于预防和/或治疗急性肾损伤（AKI）、慢性肾病、糖尿病肾病、节段性肾小球硬化、肾病综合征、肾纤维化和肾癌。
• Methods for treating liver or pancreatic cancer
  申请人：Fundación Centro Nacional De Investigaciones Oncológicas Carlos III

  公开号：EP2979706A1

  公开（公告）日：2016-02-03

  The invention relates to nicotinamide riboside or a derivative thereof for use in the treatment and/or prevention of liver or pancreatic cancer in a subject. Additionally, the invention relates to an in vitro method for designing a customized therapy for a subject diagnosed with a liver cancer or pancreatic cancer or suffering early signs of chronic liver damage or pancreatic intraepithelial lesions based on determining the level of DNA damage. Additionally the invention also relates to a method for diagnosing liver cancer and for predicting the risk of developing liver cancer in a subject suffering hepatitis. The invention also relates to a kit and their use in the methods of the invention.

  本发明涉及用于治疗和/或预防受试者肝癌或胰腺癌的烟酰胺核苷或其衍生物。此外，本发明还涉及一种体外方法，用于根据 DNA 损伤程度为诊断出患有肝癌或胰腺癌或患有慢性肝损伤早期症状或胰腺上皮内病变的受试者设计定制疗法。此外，本发明还涉及一种诊断肝癌和预测肝炎患者罹患肝癌风险的方法。本发明还涉及一种试剂盒及其在本发明方法中的用途。
• PTEROSTILBENE AND SILIBININ FOR PREVENTING, AMELIORATING OR REDUCING RADIATION-INDUCED DISEASES
  申请人：Universitat de València

  公开号：EP4029496A1

  公开（公告）日：2022-07-20

  The present invention relates to compositions comprising Pterostilbene, or a pharmaceutically acceptable salt thereof, in combination with Silibinin, or a pharmaceutically acceptable salt thereof, and their use in the treatment, prevention, amelioration or reduction of diseases induced by ionizing radiation in a subject. The compositions and the uses can further comprise at least one or more radiomitigator compound/s, preferably NAD+ boosters and/or FSL-1.

  本发明涉及包含紫檀芪或其药学上可接受的盐与西利宾或其药学上可接受的盐的组合物，以及它们在治疗、预防、改善或减少受试者由电离辐射诱发的疾病中的用途。这些组合物和用途可进一步包含至少一种或多种辐射诱导化合物，优选 NAD+ 促进剂和/或 FSL-1。
• Multi-component skin care product
  申请人：The Procter & Gamble Company

  公开号：US11013678B2

  公开（公告）日：2021-05-25

  A skin care product is provided. The skin care product includes a multi-component skin care composition disposed in a multi-chamber container. The multi-component skin care composition includes an aqueous carrier component and a nicotinamide riboside component disposed in separate chambers, which prevents these components from contacting one another prior to use. The aqueous carrier component and the nicotinamide riboside component can be separated from one another by one or more fluid impermeable dividing members and/or activatable elements, which upon activation enable contact between the aqueous carrier component and nicotinamide riboside component.

  我们提供了一种护肤产品。该护肤品包括一种置于多室容器中的多组分护肤组合物。多组分护肤组合物包括水性载体成分和烟酰胺核糖苷成分，这两种成分分别置于不同的腔室中，可防止这些成分在使用前相互接触。水性载体成分和烟酰胺核糖苷成分可以通过一个或多个液体不可渗透的分隔部件和/或可激活元件彼此隔开，激活后可使水性载体成分和烟酰胺核糖苷成分接触。