*7-[2-(acetylaminomethyl)morpholino]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | 122894-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: *7-[2-(acetylaminomethyl)morpholino]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 7-[2-(acetylaminomethyl)morpholino]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid；7-[2-(Acetamidomethyl)morpholin-4-yl]-1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 122894-05-7
• 化学式: C₂₀H₂₁F₂N₃O₅
• 分子量: 421.401
• InChiKey: LDNQYBHILWUHMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  99.2
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  *7-[2-(acetylaminomethyl)morpholino]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 以50.1的产率得到腺苷三磷酸酶抑制剂3钠钾
  参考文献：
  名称：

  Quinolonecarboxylic acid compounds and pharmaceutical use thereof

  摘要：

  一种喹诺酸类化合物的公式为：##STR1##其中，R.sup.1是烷基，环烷基，卤代烷基，烯基，单烷基或双烷基氨基，苯基或苯基上有一到三个取自卤素原子，烷基，烷氧基，羟基，硝基或氨基的取代基，R.sup.2是氢原子，烷基，环烷基，酰基或烷氧羰基，R.sup.3是氢原子，烷基或苯基甲基，或R.sup.2和R.sup.3与相邻的氮原子一起形成杂环，R.sup.4是氢原子或烷基，R.sup.5是氢原子，烷基，苯基甲基或易于在体内水解的酯基，X是氢原子，卤素原子或烷基，n是1到3的整数，以及其盐和药物用途。这些化合物表现出抗菌活性，可用于治疗各种传染病。

  公开号：

  US04889857A1
• 作为产物：
  描述：

  2-[(4-苄基-2-吗啉基)甲基]-1H-异吲哚-1,3(2H)-二酮 在 palladium on activated charcoal 一水合肼 、 三乙胺 作用下， 以 乙醇 、 异丙醇 、 甲苯 、 乙腈 为溶剂， 反应 17.0h， 生成 *7-[2-(acetylaminomethyl)morpholino]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships

  摘要：

  A series of novel 7-substituted 1-cyclopropyl-6,8-difluoro- 1,4-dihydro-4-oxo-3-quinolinecarboxylic acids have been prepared and tested for antibacterial activities and for convulsive activities in combination with nonsteroidal antiinflammatory drug. Structure-activity relationships revealed that 7-(2-(aminomethyl)morpholino) derivative 28 had a better Gram-positive activity than the reference quinolones, such as ciprofloxacin, norfloxacin, and ofloxacin. Its Gram-negative activity was equipotent with those of norfloxacin and ofloxacin but was inferior to that of ciprofloxacin. In mouse systemic infection models, 28 showed an excellent therapeutic efficacy which might result from the potent antibacterial activity and suitable physicochemical properties. Convulsive activities of 7-morpholino derivatives in combination with nonsteroidal antiinflammatory drug fenbufen or its metabolite biphenylacetic acid markedly diminished as compared to those of 7-piperazino derivatives in the electrophysiological, biochemical, and behavioral experiments. These results suggest that 28 (Y-26611) is a novel quinolone with reduced neurotoxic excitatory adverse reaction.

  DOI：

  10.1021/jm00062a007

文献信息

• Quinolonecarboxylic acid compounds and pharmaceutical use thereof
  申请人：Yoshitomi Pharmaceutical Industries, Ltd.

  公开号：US04889857A1

  公开（公告）日：1989-12-26

  A quinolonecarboxylic acid compound of the formula: ##STR1## wherein R.sup.1 is an alkyl group, a cycloalkyl group, a haloalkyl group, an alkenyl group, mono- or di-alkylamino groups, a phenyl group or a phenyl group substituted by one to three substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxy group, a hydroxy group, a nitro group or an amino group, R.sup.2 is a hydrogen atom, an alkyl group, a cycloalkyl group, an acyl group or an alkoxycarbonyl group, R.sup.3 is a hydrogen atom, an alkyl group or an aralkyl group, or R.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a heterocyclic ring, R.sup.4 is a hydrogen atom or an alkyl group, R.sup.5 is a hydrogen atom, an alkyl group, an aralkyl group or an ester residue which is readily hydrolyzable in vivo, X is a hydrogen atom, a halogen atom or an alkyl group, n is interger of 1 to 3, and a salt thereof, and pharmaceutical use thereof. The compounds exhibit antibacterial activites and are useful for the treatment of various infectious diseases.

  一种喹诺酸类化合物的公式为：##STR1##其中，R.sup.1是烷基，环烷基，卤代烷基，烯基，单烷基或双烷基氨基，苯基或苯基上有一到三个取自卤素原子，烷基，烷氧基，羟基，硝基或氨基的取代基，R.sup.2是氢原子，烷基，环烷基，酰基或烷氧羰基，R.sup.3是氢原子，烷基或苯基甲基，或R.sup.2和R.sup.3与相邻的氮原子一起形成杂环，R.sup.4是氢原子或烷基，R.sup.5是氢原子，烷基，苯基甲基或易于在体内水解的酯基，X是氢原子，卤素原子或烷基，n是1到3的整数，以及其盐和药物用途。这些化合物表现出抗菌活性，可用于治疗各种传染病。
• US4889857A
  申请人：——

  公开号：US4889857A

  公开（公告）日：1989-12-26
• Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships
  作者：Kazuhiko Araki、Tsuyoshi Kuroda、Satoru Uemori、Akihiko Moriguchi、Yoshifumi Ikeda、Fumihiro Hirayama、Yoshito Yokoyama、Eiji Iwao、Takashi Yakushiji

  DOI：10.1021/jm00062a007

  日期：1993.5

  A series of novel 7-substituted 1-cyclopropyl-6,8-difluoro- 1,4-dihydro-4-oxo-3-quinolinecarboxylic acids have been prepared and tested for antibacterial activities and for convulsive activities in combination with nonsteroidal antiinflammatory drug. Structure-activity relationships revealed that 7-(2-(aminomethyl)morpholino) derivative 28 had a better Gram-positive activity than the reference quinolones, such as ciprofloxacin, norfloxacin, and ofloxacin. Its Gram-negative activity was equipotent with those of norfloxacin and ofloxacin but was inferior to that of ciprofloxacin. In mouse systemic infection models, 28 showed an excellent therapeutic efficacy which might result from the potent antibacterial activity and suitable physicochemical properties. Convulsive activities of 7-morpholino derivatives in combination with nonsteroidal antiinflammatory drug fenbufen or its metabolite biphenylacetic acid markedly diminished as compared to those of 7-piperazino derivatives in the electrophysiological, biochemical, and behavioral experiments. These results suggest that 28 (Y-26611) is a novel quinolone with reduced neurotoxic excitatory adverse reaction.