N-methyl-N-(1H-pyrrol-1-yl)-9-β-D-ribofuranosyl-9H-purin-6-amine | 134143-52-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N-methyl-N-(1H-pyrrol-1-yl)-9-β-D-ribofuranosyl-9H-purin-6-amine
• 英文别名: N-methyl-N-(1H-pyrrol-1-yl)-9-beta-D-ribofuranosyl-9H-purin-6-amine；(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[methyl(pyrrol-1-yl)amino]purin-9-yl]oxolane-3,4-diol
• CAS: 134143-52-5
• 化学式: C₁₅H₁₈N₆O₄
• 分子量: 346.346
• InChiKey: CDOBFZJGOCMVCU-SDBHATRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  6-氯嘌呤核苷 、 N-methyl-1H-pyrrol-1-amine 在 calcium carbonate 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 N-methyl-N-(1H-pyrrol-1-yl)-9-β-D-ribofuranosyl-9H-purin-6-amine
  参考文献：
  名称：

  N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents

  摘要：

  本发明涉及一种具有以下结构的N-杂环芳基嘌呤-6-胺化合物：其中R.sub.1为氢、较低烷基和芳基较低烷基；R.sub.2和R.sub.3独立地为氢、较低烷基或R.sub.2和R.sub.3同时为芳基；R.sub.4和R.sub.5独立地为氢、较低烷基，或R.sub.4和R.sub.5同时为芳基；R.sub.6为氢、较低烷基、芳基、芳基较低烷基、其中R.sub.2、R.sub.3、R.sub.4和R.sub.5如上定义，以及其药学上可接受的酸盐，以及适用的几何和光学异构体和消旋混合物。本发明的化合物显示出作为镇痛和抗抽搐剂的效用。

  公开号：

  US05017578A1

文献信息

• N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05155098A1

  公开（公告）日：1992-10-13

  This invention relates to a N-heteroaryl-purin-6-amine of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, and arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or R.sub.4 and R.sub.5 taken together are aryl; R.sub.6 is hydrogen, lower alkyl, aryl, arylloweralkyl, ##STR2## where R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anitconvulsant agents.

  本发明涉及式为##STR1##的N-杂环芳基嘌呤-6-胺，其中R.sub.1为氢、低碳基和芳基低碳基；R.sub.2和R.sub.3独立地为氢、低碳基或R.sub.2和R.sub.3一起为芳基；R.sub.4和R.sub.5独立地为氢、低碳基或R.sub.4和R.sub.5一起为芳基；R.sub.6为氢、低碳基、芳基、芳基低碳基、##STR2##其中R.sub.2、R.sub.3、R.sub.4和R.sub.5如上所定义，以及其药学上可接受的酸加合物，适用时还包括其几何和光学异构体和外消旋混合物。本发明化合物具有镇痛和抗惊厥活性。
• N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0402752A1

  公开（公告）日：1990-12-19

  This invention relates to a N-heteroaryl-purin-6-amine of the formula where R₁ is hydrogen, lower alkyl, and arylloweralkyl; R₂ and R₃ are independently hydrogen, lower alkyl or R₂ and R₃ taken together are aryl; R₄ and R₅ are independently hydrogen, lower alkyl, or R₄ and R₅ taken together are aryl; R₆ is hydrogen, lower alkyl, aryl, arylloweralkyl, where R₂, R₃, R₄ and R₅ are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anticonvulsant agents.

  本发明涉及一种 N-杂芳基嘌呤-6-胺，其式如下 其中 R₁ 是氢、低级烷基和芳基低级烷基；R₂ 和 R₃ 独立地是氢、低级烷基或 R₂ 和 R₃ 合在一起是芳基；R₄ 和 R₅ 独立地是氢、低级烷基或 R₄ 和 R₅ 合在一起是芳基；R₆ 是氢、低级烷基、芳基、芳基低级烷基、 其中 R₂、R₃、R₄ 和 R₅ 如上文所定义，以及它们的药学上可接受的酸加成盐，并酌情包括它们的几何异构体、光学异构体和外消旋混合物。本发明的化合物可用作镇痛剂和抗惊厥剂。
• US5017578A
  申请人：——

  公开号：US5017578A

  公开（公告）日：1991-05-21
• US5155098A
  申请人：——

  公开号：US5155098A

  公开（公告）日：1992-10-13
• N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05017578A1

  公开（公告）日：1991-05-21

  This invention relates to a N-heteroaryl-purin-6-amine of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, and arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or R.sub.4 and R.sub.5 taken together are aryl; R.sub.6 is hydrogen, lower alkyl, aryl, arylloweralkyl, ##STR2## where R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anticonvulsant agents.

  本发明涉及一种具有以下结构的N-杂环芳基嘌呤-6-胺化合物：其中R.sub.1为氢、较低烷基和芳基较低烷基；R.sub.2和R.sub.3独立地为氢、较低烷基或R.sub.2和R.sub.3同时为芳基；R.sub.4和R.sub.5独立地为氢、较低烷基，或R.sub.4和R.sub.5同时为芳基；R.sub.6为氢、较低烷基、芳基、芳基较低烷基、其中R.sub.2、R.sub.3、R.sub.4和R.sub.5如上定义，以及其药学上可接受的酸盐，以及适用的几何和光学异构体和消旋混合物。本发明的化合物显示出作为镇痛和抗抽搐剂的效用。