3,4,5,6-四羟基-2-氧代己酸 | 91548-32-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3,4,5,6-四羟基-2-氧代己酸
• 英文名称: L-lyxo-[2]hexulosonic acid
• 英文别名: L-lyxo-[2]Hexulosonsaeure；2-deoxy-2-oxogulonic acid；2-Ketogulonsaeure；L-lyxo-Hexulosonic acid；(3R,4R,5S)-3,4,5,6-tetrahydroxy-2-oxohexanoic acid
• CAS: 91548-32-2
• 化学式: C₆H₁₀O₇
• 分子量: 194.141
• InChiKey: VBUYCZFBVCCYFD-PZGQECOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,4,5,6-四羟基-2-氧代己酸 在 重氮甲烷 、 甲醇 、 乙醚 作用下， 生成 维生素 C
  参考文献：
  名称：

  CH194281

  摘要：

  公开号：
• 作为产物：
  描述：

  半乳糖酸內酯 在 sodium chlorate 、 水 、 phosphorus pentoxide 、 vanadia 、 溶剂黄146 作用下， 生成 3,4,5,6-四羟基-2-氧代己酸
  参考文献：
  名称：

  Bench to Bedside Resuscitation from Prolonged Ventricular Fibrillation

  摘要：

  AbstractVentricular fibrillation (VF) remains the most common cardiac arrest heart rhythm. Defibrillation is the primary treatment and is very effective if delivered early within a few minutes of onset of VF. However, successful treatment of VF becomes increasingly more difficult when the duration of VF exceeds 4 minutes. Classically, successful cardiac arrest resuscitation has been thought of as simply achieving restoration of spontaneous circulation (ROSC). However, this traditional approach fails to consider the high early post—cardiac arrest mortality and morbidity and ignores the reperfusion injuries, which are manifest in the heart and brain. More recently, resuscitation from cardiac arrest has been divided into two phases; phase I, achieving ROSC, and phase II, treatment of reperfusion injury. The focus in both phases of resuscitation remains the heart and brain, as prolonged VF remains primarily a two‐organ disease. These two organs are most sensitive to oxygen and substrate deprivation and account for the vast majority of early post‐resuscitation mortality and morbidity. This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain.

  DOI：

  10.1111/j.1553-2712.2001.tb01155.x

文献信息

• CH199598
  申请人：——

  公开号：——

  公开（公告）日：——
• US4314055A
  申请人：——

  公开号：US4314055A

  公开（公告）日：1982-02-02
• Bench to Bedside Resuscitation from Prolonged Ventricular Fibrillation
  作者：Mark G. Angelos、James J. Menegazzi、Clifton W. Callaway

  DOI：10.1111/j.1553-2712.2001.tb01155.x

  日期：2001.9

  AbstractVentricular fibrillation (VF) remains the most common cardiac arrest heart rhythm. Defibrillation is the primary treatment and is very effective if delivered early within a few minutes of onset of VF. However, successful treatment of VF becomes increasingly more difficult when the duration of VF exceeds 4 minutes. Classically, successful cardiac arrest resuscitation has been thought of as simply achieving restoration of spontaneous circulation (ROSC). However, this traditional approach fails to consider the high early post—cardiac arrest mortality and morbidity and ignores the reperfusion injuries, which are manifest in the heart and brain. More recently, resuscitation from cardiac arrest has been divided into two phases; phase I, achieving ROSC, and phase II, treatment of reperfusion injury. The focus in both phases of resuscitation remains the heart and brain, as prolonged VF remains primarily a two‐organ disease. These two organs are most sensitive to oxygen and substrate deprivation and account for the vast majority of early post‐resuscitation mortality and morbidity. This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain.
• CH194281
  申请人：——

  公开号：——

  公开（公告）日：——