2-Bromo-1-[tri(propan-2-yl)silyl]-1H-indole | 918148-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Bromo-1-[tri(propan-2-yl)silyl]-1H-indole
• 英文别名: (2-bromoindol-1-yl)-tri(propan-2-yl)silane
• CAS: 918148-84-2
• 化学式: C₁₇H₂₆BrNSi
• 分子量: 352.39
• InChiKey: HLNARDHOORVRTJ-UHFFFAOYSA-N

物化性质

• 沸点：
  331.8±25.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.43
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-Bromo-1-[tri(propan-2-yl)silyl]-1H-indole 在 盐酸 、 tris-(dibenzylideneacetone)dipalladium(0) 、 三叔丁基膦 、 溶剂黄146 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 26.0h， 生成
  参考文献：
  名称：

  신규한 화합물 및 이를 포함하는 유기발광소자

  摘要：

  该专利涉及一种新化合物，特别适用于有机发光器件，具有优异的正电荷和电子传输特性，同时可以实现高三重态能量和高Tg，并且能够实现低驱动电压、低功耗、高效率和长寿命的有机发光器件。

  公开号：

  KR20150124911A
• 作为产物：
  描述：

  三异丙基氯硅烷 在 N-溴代丁二酰亚胺(NBS) 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 2-Bromo-1-[tri(propan-2-yl)silyl]-1H-indole
  参考文献：
  名称：

  A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan

  摘要：

  Asymmetric hydrogenation of a protected (Z)-dehydro-beta-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-beta-methyltryptophan 1. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00604-2

文献信息

• Process for Preparing Optically Active Aminopentane Derivative, Intermediate and Process for Preparing Intermediate
  申请人：Yoneda Fumio

  公开号：US20090124813A1

  公开（公告）日：2009-05-14

  There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

  提供了一种制备光学活性氨基戊烷衍生物的方法，该衍生物可作为精神药物、抗抑郁药物、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等，一种新型光学活性中间体噁嗪硫脲环衍生物，非常有用于制备氨基戊烷衍生物；以及其生产方法。光学活性氨基戊烷衍生物可以从新型光学活性噁嗪硫脲环衍生物中工业上优势地生产，该噁嗪硫脲环衍生物的化学式表示为（5）：其中*表示R或S构型的不对称碳原子的位置，n为0或1。
• Process for preparing optically active aminopentane derivative, intermediate and process for preparing intermediate
  申请人：Fujimoto Co., Ltd.

  公开号：US08178686B2

  公开（公告）日：2012-05-15

  There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

  提供了一种制备具有潜在作为精神药物、抗抑郁药物、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等作用的光学活性氨基戊烷衍生物的过程；一种新型光学活性中间体噁噻唑啉衍生物，在氨基戊烷衍生物的生产中非常有用；以及其生产过程。这些光学活性氨基戊烷衍生物可以从式（5）所表示的新型光学活性噁噻唑啉衍生物中以工业上优势的方式生产出来：其中*表示R或S构型的不对称碳原子的位置，n为0或1。
• PROCESS FOR PREPARING OPTICALLY ACTIVE AMINOPENTANE DERIVATIVE, INTERMEDIATE AND PROCESS FOR PREPARING INTERMEDIATE
  申请人：Yoneda Fumio

  公开号：US20100324300A1

  公开（公告）日：2010-12-23

  There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

  提供一种制备具有潜在作为精神药物、抗抑郁药、抗帕金森病药物、抗阿尔茨海默病药物、凋亡抑制剂等作用的光学活性氨基戊烷衍生物的方法；一种非常有用于氨基戊烷衍生物生产的新型光学活性内酰胺噻唑环衍生物；以及其生产方法。这些光学活性氨基戊烷衍生物可以从由式（5）表示的新型光学活性内酰胺噻唑环衍生物中以工业上的有利方式生产出来：其中*表示R或S构型的不对称碳原子的位置，n为0或1。
• 신규한 화합물 및 이를 포함하는 유기발광소자
  申请人：DONGJIN SEMICHEM CO., LTD. 주식회사 동진쎄미켐(119981067679) Corp. No ▼ 120111-0003848BRN ▼137-81-07814

  公开号：KR20150124911A

  公开（公告）日：2015-11-06

  본 발명은 신규한 화합물에 관한 것으로, 특히 유기발광소자에 적용시 정공 및 전자 전달 특성이 우수하고, 동시에 높은 삼중항 에너지 및 높은 Tg를 구현할 수 있으며, 낮은 구동전압, 저소비전력, 고효율 및 장수명을 가지게 할 수 있는 신규한 화합물 및 이를 포함하는 유기발광소자에 관한 것이다.

  该专利涉及一种新化合物，特别适用于有机发光器件，具有优异的正电荷和电子传输特性，同时可以实现高三重态能量和高Tg，并且能够实现低驱动电压、低功耗、高效率和长寿命的有机发光器件。
• A highly enantioselective asymmetric hydrogenation route to β-(2R,3S)-methyltryptophan
  作者：R. Scott Hoerrner、David Askin、R.P. Volante、Paul J. Reider

  DOI：10.1016/s0040-4039(98)00604-2

  日期：1998.5

  Asymmetric hydrogenation of a protected (Z)-dehydro-beta-methyltryptophan derivative 2 with (R,R)-Me-DuPHOS-Rh catalysis was achieved in 97 % ee. Deprotection then afforded (2R,3S)-beta-methyltryptophan 1. (C) 1998 Elsevier Science Ltd. All rights reserved.