3-methylazulene-1-carboxyhydrazide | 1159168-73-6

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 3-methylazulene-1-carboxyhydrazide
• 英文别名: 3-Methylazulene-1-carbohydrazide
• CAS: 1159168-73-6
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: HYCXMPKPNDNCKM-UHFFFAOYSA-N

物化性质

• 熔点：
  151-152 °C(Solvent: Ethanol)
• 密度：
  1.196±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methylazulene-1-carboxyhydrazide 、 水杨酸 在 三氯氧磷 作用下， 反应 0.17h， 以83%的产率得到5-(2-hydroxyphenyl)-2-(3-methylazulen-1-yl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Microwave-Assisted Synthesis and Antifungal Activity of 2,5-Disubstituted-1,3,4-oxadiazoles Containing Azulene Moiety

  摘要：

  Microwave-assisted as well as conventional synthesis of 2,5-disubstituted-1,3,4-oxadiazoles containing the azulene moiety was carried out, and their antifungal activity is also reported.

  DOI：

  10.1080/00397910802654658
• 作为产物：
  描述：

  methyl 3-methylazulene-1-carboxylate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以87%的产率得到3-methylazulene-1-carboxyhydrazide
  参考文献：
  名称：

  Microwave-Assisted Synthesis and Antifungal Activity of 2,5-Disubstituted-1,3,4-oxadiazoles Containing Azulene Moiety

  摘要：

  Microwave-assisted as well as conventional synthesis of 2,5-disubstituted-1,3,4-oxadiazoles containing the azulene moiety was carried out, and their antifungal activity is also reported.

  DOI：

  10.1080/00397910802654658

文献信息

• Microwave-Assisted Synthesis and Antifungal Activity of 2,5-Disubstituted-1,3,4-oxadiazoles Containing Azulene Moiety
  作者：Jiao Xu、Dao-Lin Wang、Kimiaki Imafuku

  DOI：10.1080/00397910802654658

  日期：2009.5.22

  Microwave-assisted as well as conventional synthesis of 2,5-disubstituted-1,3,4-oxadiazoles containing the azulene moiety was carried out, and their antifungal activity is also reported.