5-(4-chlorophenyl)-2-(3-methylazulen-1-yl)-1,3,4-oxadiazole | 1173810-14-4

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 5-(4-chlorophenyl)-2-(3-methylazulen-1-yl)-1,3,4-oxadiazole
• 英文别名: 2-(4-Chlorophenyl)-5-(3-methylazulen-1-yl)-1,3,4-oxadiazole
• CAS: 1173810-14-4
• 化学式: C₁₉H₁₃ClN₂O
• 分子量: 320.778
• InChiKey: RLKFWRUHXHOZNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-methylazulene-1-carboxyhydrazide 、 对氯苯甲酸 在 三氯氧磷 作用下， 反应 0.2h， 以82%的产率得到5-(4-chlorophenyl)-2-(3-methylazulen-1-yl)-1,3,4-oxadiazole
  参考文献：
  名称：

  Microwave-Assisted Synthesis and Antifungal Activity of 2,5-Disubstituted-1,3,4-oxadiazoles Containing Azulene Moiety

  摘要：

  Microwave-assisted as well as conventional synthesis of 2,5-disubstituted-1,3,4-oxadiazoles containing the azulene moiety was carried out, and their antifungal activity is also reported.

  DOI：

  10.1080/00397910802654658

文献信息

• Microwave-Assisted Synthesis and Antifungal Activity of 2,5-Disubstituted-1,3,4-oxadiazoles Containing Azulene Moiety
  作者：Jiao Xu、Dao-Lin Wang、Kimiaki Imafuku

  DOI：10.1080/00397910802654658

  日期：2009.5.22

  Microwave-assisted as well as conventional synthesis of 2,5-disubstituted-1,3,4-oxadiazoles containing the azulene moiety was carried out, and their antifungal activity is also reported.