2-bromo-1-(5-chloro-2-hydroxy-phenyl)-2-methyl-propan-1-one | 82320-27-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-1-(5-chloro-2-hydroxy-phenyl)-2-methyl-propan-1-one
• 英文别名: 2-Brom-1-(5-chlor-2-hydroxy-phenyl)-2-methyl-propan-1-on；4-Chloro-2-(2-bromoisobutyryl)phenol；2-bromo-1-(5-chloro-2-hydroxyphenyl)-2-methylpropan-1-one
• CAS: 82320-27-2
• 化学式: C₁₀H₁₀BrClO₂
• 分子量: 277.545
• InChiKey: SVBTVWFAWUFLGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-1-(5-chloro-2-hydroxy-phenyl)-2-methyl-propan-1-one 生成 5-chloro-2,2-dimethyl-benzofuran-3-one
  参考文献：
  名称：

  UEDA, KOUICHIRO;TANAKA, SATORU;KUNII, TOSHINOBU;KAGEI, KENGO;SATO, TADASH+

  摘要：

  DOI：
• 作为产物：
  描述：

  4-chlorophenyl 2-methylpropionate 在 二硫化碳 、 三氯化铝 、 溴 作用下， 生成 2-bromo-1-(5-chloro-2-hydroxy-phenyl)-2-methyl-propan-1-one
  参考文献：
  名称：

  v.Auwers; Baum; Lorenz, Journal fur praktische Chemie (Leipzig 1954), 1927, vol. <2>115, p. 90

  摘要：

  DOI：

文献信息

• Hydantoin derivatives for treating complications of diabetes
  申请人：Eisai Co., Ltd.

  公开号：US04780472A1

  公开（公告）日：1988-10-25

  Hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein the substituents are defined hereinbelow. The hydantoin derivatives and salts thereof have excellent effects for the treamtment of the complications of the diabetes mellitus.

  Hydantoin衍生物及其盐的制备方法和含有它们的药物，其中Hydantoin衍生物由下列通式表示：##STR1## 其中取代基的定义如下。Hydantoin衍生物及其盐对治疗糖尿病并发症具有出色的效果。
• Treating complications of diabetes mellitus with hydantoin derivatives
  申请人：Eisai Co., Ltd.

  公开号：US04540704A1

  公开（公告）日：1985-09-10

  Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, independently represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y represents an oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, independently represent a hydrogen atom, a lower alkyl group or phenyl group, or both may form a ring with carbon atoms, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom, and n represents 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of diabetes mellitus.

  新型的恶唑啉衍生物及其盐，制备方法和含有它们的药物，其中恶唑啉衍生物由通式表示：##STR1## 其中X1和X2，可能相同或不同，独立地表示氢原子、卤素原子、低级烷基或低级烷氧基；Y表示氧原子或硫原子，R1和R2，可能相同或不同，独立地表示氢原子、低级烷基或苯基，或者两者可以与碳原子形成环，但不包括R1和R2都是氢原子的情况，n表示0或1。这些新型的恶唑啉衍生物及其盐对于治疗糖尿病并发症具有出色的疗效。
• Hydantoin derivatives and medicines containing the same
  申请人：Eisai Co., Ltd.

  公开号：US04874869A1

  公开（公告）日：1989-10-17

  Novel hydantoin derivatives and salts thereof, the process for the preparation thereof, and medicines containing the same, wherein the hydantoin derivatives are represented by the general formula: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, mean independently hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; Y means oxygen atom or sulfur atom, R.sub.1 and R.sub.2, which may be the same or different, mean independently hydrogen atom, a lower alkyl group or phenyl group, or the both may form a ring with a carbon atom which is combined with them, excluding the case wherein both R.sub.1 and R.sub.2 are hydrogen atom at the same time, and n means an integer of 0 or 1. The novel hydantoin derivatives and salts thereof have excellent effects for the treatment of the complications of the diabetes mellitus.

  新型的氨基咪唑衍生物及其盐，制备方法和含有它们的药物。其中，氨基咪唑衍生物由通式所示：##STR1##其中X1和X2可以相同也可以不同，分别表示氢原子、卤素原子、低碳基或低烷氧基；Y表示氧原子或硫原子；R1和R2可以相同也可以不同，分别表示氢原子、低碳基或苯基，或两者可以与它们结合的碳原子形成环，除非R1和R2同时为氢原子的情况，n表示0或1的整数。这些新型的氨基咪唑衍生物及其盐对于糖尿病并发症的治疗具有优秀的效果。
• UEDA, KOUICHIRO;TANAKA, SATORU;KUNII, TOSHINOBU;KAGEI, KENGO;SATO, TADASH+
  作者：UEDA, KOUICHIRO、TANAKA, SATORU、KUNII, TOSHINOBU、KAGEI, KENGO、SATO, TADASH+

  DOI：——

  日期：——
• UEDA, KOUICHIRO;SATORU, TANAKA;KUNII, TOSHINOBU;KAGEL, KENGO;SATO, TADASH+
  作者：UEDA, KOUICHIRO、SATORU, TANAKA、KUNII, TOSHINOBU、KAGEL, KENGO、SATO, TADASH+

  DOI：——

  日期：——