4-Allyloxy-chinolin | 1203-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Allyloxy-chinolin
• 英文别名: 4-Allyloxyquinoline；4-prop-2-enoxyquinoline
• CAS: 1203-82-3
• 化学式: C₁₂H₁₁NO
• 分子量: 185.225
• InChiKey: FMRKKMWOZCJSPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Allyloxy-chinolin 在 1,2-双(二苯基膦)乙烷 、 cobalt(II) bromide 、 zinc(II) iodide 、 锌 作用下， 以 乙腈 为溶剂， 以74 %的产率得到4-羟基喹啉
  参考文献：
  名称：

  Low‐Valent Cobalt‐Catalyzed Deprotection of Allyloxyarenes

  摘要：

  AbstractHerein, we report a low‐valent cobalt‐catalyzed deprotection of allyloxyarenes. The method displays a broad substrate scope and good functional group tolerance, granting its utilization on more complex substrates, includingO‐allylated derivatives of natural products and drugs. Based on comprehensive experiments, a plausible mechanistic pathway for the low‐valent cobalt‐catalyzedO‐deallylation of allyloxyarenes is proposed.

  DOI：

  10.1002/ejoc.202201112
• 作为产物：
  描述：

  4-羟基喹啉 、 3-溴丙烯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以14 %的产率得到4-Allyloxy-chinolin
  参考文献：
  名称：

  Low‐Valent Cobalt‐Catalyzed Deprotection of Allyloxyarenes

  摘要：

  AbstractHerein, we report a low‐valent cobalt‐catalyzed deprotection of allyloxyarenes. The method displays a broad substrate scope and good functional group tolerance, granting its utilization on more complex substrates, includingO‐allylated derivatives of natural products and drugs. Based on comprehensive experiments, a plausible mechanistic pathway for the low‐valent cobalt‐catalyzedO‐deallylation of allyloxyarenes is proposed.

  DOI：

  10.1002/ejoc.202201112

文献信息

• BRIDGED CARBAMATE MACROLIDES
  申请人：Kim Heejin

  公开号：US20080027012A1

  公开（公告）日：2008-01-31

  The present invention discloses compounds of formulae (I) and (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

  本发明公开了式(I)和(II)的化合物或其药学上可接受的盐、酯或前药：这些化合物具有抗菌性能。本发明还涉及含有上述化合物的药物组合物，用于治疗需要抗生素治疗的受试者。该发明还涉及通过给予含有本发明化合物的药物组合物来治疗受试者的细菌感染的方法。该发明还包括制备本发明化合物的方法。
• 3,6-Bridged 9,12-oxolides
  申请人：Or Sun Yat

  公开号：US20070232554A1

  公开（公告）日：2007-10-04

  The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

  本发明揭示了公式（I）的化合物或其药学上可接受的盐、酯或前药：具有抗菌性能。本发明还涉及包含上述化合物的制药组合物，用于治疗需要抗生素治疗的受体。本发明还涉及通过给予包含本发明化合物的制药组合物来治疗受体的细菌感染的方法。本发明还包括制备本发明化合物的方法。
• US7291602B2
  申请人：——

  公开号：US7291602B2

  公开（公告）日：2007-11-06
• US7312201B2
  申请人：——

  公开号：US7312201B2

  公开（公告）日：2007-12-25
• US7407942B2
  申请人：——

  公开号：US7407942B2

  公开（公告）日：2008-08-05