(2-aminophenyl)(pyridin-3-yl)methanone | 3882-48-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-aminophenyl)(pyridin-3-yl)methanone
• 英文别名: 2-aminophenyl-(3-pyridinyl)methanone；(2-Aminophenyl)(3-pyridinyl)methanone；(2-aminophenyl)-pyridin-3-ylmethanone
• CAS: 3882-48-2
• 化学式: C₁₂H₁₀N₂O
• 分子量: 198.224
• InChiKey: KNZLZNHWLVEHCZ-UHFFFAOYSA-N

物化性质

• 熔点：
  247-249 °C
• 沸点：
  413.1±25.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-aminophenyl)(pyridin-3-yl)methanone 在 硫酸 、 sodium nitrite 、 铜 、 尿素 作用下， 以 水 为溶剂， 反应 1.25h， 以40%的产率得到4-氮杂-9-芴酮
  参考文献：
  名称：

  An investigation on the second-order NLO properties of novel cationic cyclometallated Ir(III) complexes of the type [Ir(2-phenylpyridine)2(9-R-4,5-diazafluorene)]+ (R=H, fulleridene) and the related neutral complex with the new 9-fulleriden-4-monoazafluorene ligand

  摘要：

  Novel cationic cyclometallated Ir(III) complexes bearing diaza-or monoazafluorene substituted or not with a C60-fullerene moiety have been synthesized together with a novel interesting ligand 9-fulleriden-4-monoazafluorene and the related Ir(III) neutral complex [Ir(ppy)(2)(9-fulleriden-4-monoazafluorene)]. All complexes show a negative large value of mu beta(1.907) (600 to 2190 x 10(-48) esu), as determined by the Electric Field Induced Second Harmonic generation (EFISH) technique working at 1.907 mu m in 10(-3)M CH2Cl2 solution. The NLO response increases upon introduction of the fullerene moiety, due to a decrease of the interaction forces between the anion and cation within the ion pair which leads to an increase of the percentage of free ions, as evidenced by diffusion NMR experiments. Besides, it appeared that for the neutral complex [Ir(ppy)(2)(9-fulleriden-4-monoazafluorene)] the EFISH mu beta(1.907) value is lower than that of cationic Ir(III) complexes, but comparable or slightly lower to the values of other neutral Ir(III) complexes such as [Ir(ppy)(2)(RCOCR'COR)] (ppy = cyclometallated 2-phenylpyridine; R = Me, Ph; R' = H, 2,4-dinitrophenyl), confirming that the second-order NLO response of these neutral chromophores is dominated by ILCT processes concerning cyclometallated 2-phenylpyridines. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.10.018
• 作为产物：
  描述：

  (2-nitrophenyl)(pyridin-3-yl)methanol 在 铂 manganese(IV) oxide 、 氢气 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 26.0h， 生成 (2-aminophenyl)(pyridin-3-yl)methanone
  参考文献：
  名称：

  Street, Jonathan D.; Baradarani, M. Mehdi; Beddoes, Roy L., Journal of Chemical Research, Miniprint, 1987, # 5, p. 1247 - 1285

  摘要：

  DOI：

文献信息

• 2-Aminobenzophenones as a Novel Class of Bradykinin B₁Receptor Antagonists
  作者：Dai-Shi Su、John L. Lim、Elizabeth Tinney、Bang-Lin Wan、Kathy L. Murphy、Duane R. Reiss、C. Meacham Harrell、Stacy S. O’Malley、Rick W. Ransom、Raymond S. L. Chang、Douglas J. Pettibone、Jian Yu、Cuyue Tang、Thomayant Prueksaritanont、Roger M. Freidinger、Mark G. Bock、Neville J. Anthony

  DOI：10.1021/jm800199h

  日期：2008.7

  Selective bradykinin (BK) B 1 receptor antagonists could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure activity relationships of the structurally novel HTS lead compound 1 provided potent hBK B 1 receptor antagonists with excellent receptor occupancy in the CNS of hBK B 1 transgenic rats.

  选择性缓激肽（BK）B 1受体拮抗剂可能是治疗疼痛和炎症的新型治疗剂。对结构新颖的HTS前导化合物1的结构活性关系的阐明提供了有效的hBK B 1受体拮抗剂，在hBK B 1转基因大鼠的中枢神经系统中具有出色的受体占有率。
• Deoxygenative Arylation of Carboxylic Acids by Aryl Migration
  作者：Rehanguli Ruzi、Junyang Ma、Xiang‐Ai Yuan、Wenliang Wang、Shanshan Wang、Muliang Zhang、Jie Dai、Jin Xie、Chengjian Zhu

  DOI：10.1002/chem.201903816

  日期：2019.10

  phosphoranyl radical chemistry allows for precise cleavage of a stronger C-O bond and formation of a weaker C-C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral

  已经实现了前所未有的芳香族羧酸脱氧芳基化反应，从而可以构建增强的不对称二芳基酮库。协同的光氧化还原催化作用和磷烷基自由基化学反应可在温和的反应条件下，通过1,5-芳基迁移，精确裂解更强的CO键并形成较弱的CC键。此新协议独立于底物氧化还原电势，电子和取代基效应。在氧化还原中性条件下，它提供了60种合成通用的邻氨基和邻羟基二芳基酮的通用且有希望的途径。此外，以令人满意的产率，它也为全合成喹诺酮生物碱，（±）-yaequinolone A2和viridicatin衍生物提供了一条简洁的途径。
• Development of 1,4-benzodiazepine cholecystokinin type B antagonists
  作者：Mark G. Bock、Robert M. DiPardo、Ben E. Evans、Kenneth E. Rittle、Willie L. Whitter、Victor M. Garsky、Kevin F. Gilbert、James L. Leighton、Kenneth L. Carson

  DOI：10.1021/jm00078a018

  日期：1993.12

  4-benzodiazepines, nonpeptidal antagonists of the peptide hormone cholecystokinin (CCK), are described. Derived by reasoned modification of the CCK-A selective 3-carboxamido-1,4-benzodiazepine, MK-329, this paper chronicles the development of potent, orally effective compounds in which selectivity for the CCK-B receptor subtype was achieved. The principal lead structure that emerged from these studied is

  描述了一系列3-（芳基脲基）-5-苯基-1,4-苯并二氮杂卓，肽激素胆囊收缩素（CCK）的非肽拮抗剂。通过对CCK-A选择性3-甲酰胺基-1,4-苯并二氮杂卓MK-329的合理修饰而衍生，本文记载了有效的，口服有效的化合物的开发，其中对CCK-B受体亚型具有选择性。从这些研究中得出的主要铅结构是L-365,260，该化合物已提交临床评估。讨论了通过适当的结构修饰来调节这些苯并二氮杂the的受体相互作用的能力的细节，这暗示了进一步完善这类化合物的CCK-B受体亲和力和选择性的可能性。
• 一种由芳香羧酸合成邻氨基芳香酮的方法
  申请人：南京大学

  公开号：CN109824530B

  公开（公告）日：2021-09-28

  一种由芳香羧酸制备邻氨基芳香酮的方法，它是以2‑芳基磺酰胺基芳香羧酸为原料，三苯基膦作为脱氧剂，在蓝光灯照射下，在1,4‑二氧六环溶液中，氩气气氛下，在磷酸氢二钾存在下，以[Ir(dF(CF3)ppy)2(dtbbpy)]PF6为光催化剂，得到邻氨基芳香酮化合物；所述的光催化剂[Ir(dF( )ppy)2(dtbbpy)]PF6如下结构：。
• Process and intermediates for the preparation of aryl substituted
  申请人：A. H. Robins Company, Incorporated

  公开号：US04560510A1

  公开（公告）日：1985-12-24

  A process for preparing pyrido[1,4]benzodiazepines having antidepressant activity illustrated by the formula: ##STR1## wherein Ar is pyridinyl, thienyl or phenyl; R is alkali-metal ion, hydrogen, loweralkyl or an amine or an amine precursor on the end of a hydrocarbon chain and wherein in the process condensation of an amino-chloropyridine with an aryl(aminophenyl)methanone is accomplished with a strong non-nucleophilic base in stirrable admixture with an inert liquid carrier. Alternatively, condensation is accomplished sequentially using titanium tetrachloride first followed by non-nucleophilic base.

  一种制备具有抗抑郁活性的吡啶并[1,4]苯二氮杂环己烯的方法，其示例如下：##STR1##其中Ar为吡啶基、噻吩基或苯基；R为碱金属离子、氢、较低的烷基或碳氢链末端的胺或胺前体，其中在该过程中，通过在可搅拌的惰性液体载体中与强非亲核碱一起使氨基氯吡啶与芳基(氨基苯基)甲酮发生缩合来实现。或者，可以先使用四氯化钛，然后使用非亲核碱顺序完成缩合。