3,5-二溴苯并呋喃 | 99660-97-6

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 3,5-二溴苯并呋喃
• 中文别名: 3,5-二溴苯并[b]呋喃
• 英文名称: dibromo-3,5 benzofuranne
• 英文别名: 3,5-dibromobenzofuran；3,5-dibromo-benzofuran；3,5-Dibrom-benzofuran；3,5-Dibromo-1-benzofuran
• CAS: 99660-97-6
• 化学式: C₈H₄Br₂O
• 分子量: 275.927
• InChiKey: FWNOZAIGDLGBGI-UHFFFAOYSA-N

物化性质

• 熔点：
  77 °C
• 沸点：
  294.9±20.0 °C(Predicted)
• 密度：
  1.989±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S26,S36/37/39
• 危险类别码：
  R22,R36/37/38
• 海关编码：
  2932999099

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3,5-Dibromobenzofuran
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3,5-Dibromobenzofuran
CAS number: 99660-97-6

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H4Br2O
Molecular weight: 275.9

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3,5-二溴苯并呋喃 在 硝酸 作用下， 以 乙酸酐 为溶剂， 反应 15.0h， 以24%的产率得到dibromo-3,5 nitro-2 benzofuranne
  参考文献：
  名称：

  Bachelet; Royer; Gayral, European Journal of Medicinal Chemistry, 1985, vol. 20, # 5, p. 425 - 427

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,5-tribromo-2,3-dihydrobenzofuran 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 3.5h， 以86%的产率得到3,5-二溴苯并呋喃
  参考文献：
  名称：

  Bach, Thorsten; Bartels, Marc, Synthesis, 2003, # 6, p. 925 - 939

  摘要：

  DOI：

文献信息

• Benzofuranyl 3,5-bis-Polyamine derivatives as time-Dependent inhibitors of trypanothione reductase
  作者：Chris J. Hamilton、Ahilan Saravanamuthu、Alan H. Fairlamb、Ian M. Eggleston

  DOI：10.1016/s0968-0896(03)00344-4

  日期：2003.8

  inhibitors of the protozoan oxidoreductase trypanothione reductase are reported. These molecules were designed as simplified mimetics of the naturally occurring spermidine-bridged macrocyclic alkaloid lunarine 1, a known time-dependent inhibitor of trypanothione reductase. In this series of compounds the bis-polyaminoacrylamide derivatives 2-4 were all shown to be competitive inhibitors, but only the b

  报道了作为原生动物氧化还原酶锥虫硫酮还原酶的时间依赖性抑制剂的3，5-二取代苯并呋喃衍生物的合成和评价。这些分子被设计为天然存在的亚精胺桥联的大环生物碱lunarine 1的简化模拟物，后者是一种已知的时间依赖性的锥虫硫醚还原酶抑制剂。在这一系列化合物中，双-聚氨基丙烯酰胺衍生物2-4均被证明是竞争性抑制剂，但只有双4-甲基-哌嗪-1-基-丙基丙烯酰胺衍生物4表现出时间依赖性。已经确定了1和4的时间依赖性锥虫硫醚还原酶失活的动力学，并在本文中进行了比较和讨论。
• 有机化合物、混合物、组合物及有机电子器件
  申请人：广州华睿光电材料有限公司

  公开号：CN114685454A

  公开（公告）日：2022-07-01

  本发明涉及一种有机化合物、混合物、组合物及有机电子器件。该有机化合物具有式(1)或(2)所示结构，将其用于有机电子器件中的发光层，可提高电致发光效率，并延长器件的寿命。
• NaBH4-TMEDA and a palladium catalyst as efficient regio- and chemoselective system for the hydrodehalogenation of halogenated heterocycles
  作者：Giorgio Chelucci、Susanna Figus

  DOI：10.1016/j.molcata.2014.06.012

  日期：2014.11
• BACHELET, J. -P.;ROYER, R;GAYRAL, PH., EUR. J. MED. CHEM., 1985, 20, N 5, 425-427
  作者：BACHELET, J. -P.、ROYER, R、GAYRAL, PH.

  DOI：——

  日期：——
• CN116897154
  申请人：——

  公开号：——

  公开（公告）日：——

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