(R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)-1-phenylethanamine | 1195985-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)-1-phenylethanamine
• 英文别名: (1R)-N-[(1R)-1-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]ethyl]-1-phenylethanamine
• CAS: 1195985-41-1
• 化学式: C₂₁H₂₂F₃N₃O
• 分子量: 389.42
• InChiKey: DCKITMWASKRPTH-HUUCEWRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  39.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)-1-phenylethanamine 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 (R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)-1-phenylethanamine dihydrochloride
  参考文献：
  名称：

  Discovery and Optimization of Substituted 1-(1-Phenyl-1H-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics

  摘要：

  Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relationships of various substituted heterocycles and their effects oil the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.

  DOI：

  10.1021/jm9012278
• 作为产物：
  描述：

  4-(三氟甲基)苯肼 在 titanium(IV) isopropylate 、 lithium aluminium tetrahydride 、 偶氮二甲酸二异丙酯 、 戴斯-马丁氧化剂 、 三苯基膦 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 苯 为溶剂， 反应 4.0h， 生成 (R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)ethyl)-1-phenylethanamine
  参考文献：
  名称：

  Discovery and Optimization of Substituted 1-(1-Phenyl-1H-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics

  摘要：

  Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relationships of various substituted heterocycles and their effects oil the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.

  DOI：

  10.1021/jm9012278

文献信息

• Discovery and Optimization of Substituted 1-(1-Phenyl-1<i>H</i>-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics
  作者：Steve F. Poon、David J. St. Jean、Paul E. Harrington、Charles Henley、James Davis、Sean Morony、Fred D. Lott、Jeff D. Reagan、Jenny Ying-Lin Lu、Yuhua Yang、Christopher Fotsch

  DOI：10.1021/jm9012278

  日期：2009.11.12

  Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relationships of various substituted heterocycles and their effects oil the human calcium-sensing receptor are discussed. Pyrazole 15 was shown to be efficacious in a rat in vivo pharmacodynamic model.