2-(3,5-Ditert-butyl-4-hydroxyphenyl)-7-methoxychromen-4-one | 175168-61-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,5-Ditert-butyl-4-hydroxyphenyl)-7-methoxychromen-4-one
• CAS: 175168-61-3
• 化学式: C₂₄H₂₈O₄
• 分子量: 380.484
• InChiKey: LGRBWYYOVCBMMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3,5-Ditert-butyl-4-hydroxyphenyl)-7-methoxychromen-4-one 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以84%的产率得到3',5'-di-tert.-butyl-7,4'-dihydroxyflavone
  参考文献：
  名称：

  Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart

  摘要：

  Three newly synthesised lipid peroxidation inhibitors (7, 11, 14) were evaluated for their effects on myocardial functional recovery during reperfusion after 30 min global ischemia in isolated rat hearts. The flavonoid compounds (7, 11, 14, rutin) reduce ischemia/reperfusion-induced cardiac dysfunction. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00589-8
• 作为产物：
  描述：

  3,5-di-tert-butyl-4-hydroxybenzoyl chloride 在 吡啶 、 4-二甲氨基吡啶 、 sodium hydroxide 、 硫酸 、 溶剂黄146 作用下， 以 二甲基亚砜 为溶剂， 反应 9.0h， 生成 2-(3,5-Ditert-butyl-4-hydroxyphenyl)-7-methoxychromen-4-one
  参考文献：
  名称：

  Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart

  摘要：

  Three newly synthesised lipid peroxidation inhibitors (7, 11, 14) were evaluated for their effects on myocardial functional recovery during reperfusion after 30 min global ischemia in isolated rat hearts. The flavonoid compounds (7, 11, 14, rutin) reduce ischemia/reperfusion-induced cardiac dysfunction. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00589-8

文献信息

• Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart
  作者：Jonathan Lebeau、Rémi Neviere、Nicole Cotelle

  DOI：10.1016/s0960-894x(00)00589-8

  日期：2001.1

  Three newly synthesised lipid peroxidation inhibitors (7, 11, 14) were evaluated for their effects on myocardial functional recovery during reperfusion after 30 min global ischemia in isolated rat hearts. The flavonoid compounds (7, 11, 14, rutin) reduce ischemia/reperfusion-induced cardiac dysfunction. (C) 2000 Elsevier Science Ltd. All rights reserved.