1-ethyl-4-methylquinolinium cation | 46154-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-ethyl-4-methylquinolinium cation
• 英文别名: 1-ethyl-4-methyl-quinolinium；1-ethyl-4-methyl-quinolinium cation；1-Aethyl-4-methyl-chinolinium；1-Aethyl-4-methylchinolinium；N-Ethyl-4-methyl-chinolinium；1-Ethyl-lepidinium；1-Ethyl-4-methylquinolin-1-ium
• CAS: 46154-58-9
• 化学式: C₁₂H₁₄N
• mdl: MFCD00612490
• 分子量: 172.25
• InChiKey: LCNWZISUNVZUOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-ethyl-4-methylquinolinium cation 、 4-（1,2,2-三苯基乙烯基）苯甲醛 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  基于聚集诱导发光效应的花菁荧光探针及制备方法和应用

  摘要：

  本发明公开了一种基于聚集诱导发光效应的花菁荧光探针及制备方法和应用，所述基于聚集诱导发光效应的花菁荧光探针通式为Ⅰ，结构融合TPE和花菁结构单元的分子探针，合成过程相对简单快速，在分子影像领域具有巨大的应用潜力。本发明合成的TPE化合物具有发光性能优良、合成简便、易功能化等优点，对活细胞毒性较小，具有活细胞膜通透性，可用于活细胞荧光成像；本发明的AIE效应花菁荧光分子探针合成过程相对简单快速，在分子影像领域具有巨大的应用潜力，解决了有机荧光化合物存在聚集诱导荧光淬灭的问题。

  公开号：

  CN106187880A

文献信息

• Imaging Beta-Amyloid Peptides Aggregation
  申请人：Hong Kong Baptist University

  公开号：US20160243264A1

  公开（公告）日：2016-08-25

  The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro and in vivo via magnetic resonance and florescence imaging by using modified carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using the modified carbazole-based fluorophore. The modified carbazole-based fluorophore according to an embodiment of the present invention is prepared by conjugating a carbazole-based fluorophore with magnetic nanoparticles to form a conjugate which is permeable to blood brain barrier of a subject being introduced therewith.

  本发明涉及制药和化工行业。具体而言，本发明的一个方面涉及使用改良的基于咔唑的荧光物质通过磁共振和荧光成像在体内和体外标记、成像和检测β-淀粉样蛋白（Aβ）肽、寡聚体和纤维的方法。本发明的另一个方面涉及一种减少和预防β-淀粉样蛋白在阿尔茨海默病（AD）中聚集的方法，以及使用改良的基于咔唑的荧光物质治疗和/或预防阿尔茨海默病的方法。根据本发明实施例的改良基于咔唑的荧光物质是通过将基于咔唑的荧光物质与磁性纳米颗粒偶联而制备的，形成的共轭物质能够穿透引入的受试者的血脑屏障。
• SUBSTANCES FOR DYEING KERATINOUS FIBERS
  申请人：Gross Wibke

  公开号：US20100037909A1

  公开（公告）日：2010-02-18

  Disclosed are substances which contain unsaturated, non-aromatic dialdehydes of formula (Ia) and/or the tautomer (Ib) thereof, wherein R 1 , R 2 , and R 3 are defined as indicated in claim 1 , along with at least one CH-acidic compound of formulas (II) and/or (III), wherein R 6 , R 7 , R 8 , R 9 , R 10 , Y, X − , Het, and X 1 are defined as indicated in claim 1 , in a cosmetic carrier. Said substances color keratinous fibers, especially human hair, in an intensive, colorfast, natural brown shade.

  本发明涉及一种含有式(Ia)和/或其互变异构体(Ib)的不饱和非芳香二醛的物质，其中R1、R2和R3如权利要求1所示定义，以及至少一种式(II)和/或(III)的CH-酸性化合物，其中R6、R7、R8、R9、R10、Y、X−、Het和X1如权利要求1所示定义，在一种化妆品载体中。所述物质能够使角质纤维，尤其是人类头发，在一种浓郁、色牢、自然棕色的色调中着色。
• ASYMMETRIC CYANINE FLUORESCENT DYES
  申请人：Peng Xiaojun

  公开号：US20090017441A1

  公开（公告）日：2009-01-15

  The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R 1 , R 2 , R 3 , R 4 , R 5 and Y − are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof.

  本公开提供了式I中的不对称青霉素荧光染料，其中X、n、R1、R2、R3、R4、R5和Y-如规范中所定义。本公开还提供了荧光染料的结合物，其制备方法，包含荧光染料的组合物，以及使用荧光染料和其组合物对生物样本进行染色的方法。
• Agent For Colouring Fibres Containing Keratin
  申请人：Gross Wibke

  公开号：US20080189877A1

  公开（公告）日：2008-08-14

  Fiber-coloring components for dye compositions and methods for using the same, wherein the compositions comprise: (i) at least one component A comprising a compound selected from imidazo[1,5-a]pyrimidinium derivatives of general formula I, enamine counterparts of such derivatives, and mixtures thereof: and (ii) at least one component B comprising a reactive carbonyl compound.

  纤维染色剂组成成分和使用方法，其中组成包括：(i) 至少一个A成分，包括从通式I选择的咪唑[1,5-a]嘧啶衍生物，这些衍生物的恩酰亚衍生物和它们的混合物；和 (ii) 至少一个B成分，包括反应性羰基化合物。
• Dye-Sensitized Photoelectric Conversion Device
  申请人：Shigaki Koichiro

  公开号：US20090044857A1

  公开（公告）日：2009-02-19

  Disclosed is a photoelectric conversion device wherein a methine dye represented by the formula (1) below is supported by a thin film of oxide semiconductor particles arranged on a substrate. Also disclosed is a solar cell manufactured by using such a photoelectric conversion device. (In the formula (1), n represents an integer of 0-5; m represents an integer of 0-5; R 1 -R 4 independently represent a hydrogen atom, an optionally substituted aromatic residue, an optionally substituted aliphatic hydrocarbon residue or the like; X and Y independently represent a hydrogen atom; an optionally substituted aromatic residue, an optionally substituted aliphatic hydrocarbon residue or the like; Z represents an oxygen atom, a sulfur atom or the like; A 1 , A 2 , A 3 , A 4 and A 5 independently represent a hydrogen atom, an optionally substituted aromatic residue, an optionally substituted aliphatic hydrocarbon residue or the like; and rings a, b and c may be substituted.)

  本发明公开了一种光电转换装置，其中通过在基板上排列的氧化物半导体颗粒薄膜上支持以下式(1)所表示的甲烷染料。同时，本发明还公开了使用这种光电转换装置制造的太阳能电池。(在式(1)中，n表示0-5的整数；m表示0-5的整数；R1-R4独立地表示氢原子、可选取代芳香基残基、可选取代脂肪烃基残基或类似物；X和Y独立地表示氢原子、可选取代芳香基残基、可选取代脂肪烃基残基或类似物；Z表示氧原子、硫原子或类似物；A1、A2、A3、A4和A5独立地表示氢原子、可选取代芳香基残基、可选取代脂肪烃基残基或类似物；环a、b和c可以被取代。)