3,6-二羟基吖啶 | 43129-74-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3,6-二羟基吖啶
• 英文名称: 3,6-acridinediol
• 英文别名: dihydroxy-3,6 acridine；3,6-dibydroxyacridine；acridine-3,6-diol；Acridin-3,6-diol；3,6-dihydroxyacridine；3.6-dioxy-acridin；Acridine-3,6-diol
• CAS: 43129-74-4
• 化学式: C₁₃H₉NO₂
• 分子量: 211.22
• InChiKey: LXFYIIKDJZNGST-UHFFFAOYSA-N

物化性质

• 熔点：
  >300℃

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,6-二羟基吖啶 在 吡啶 、 palladium diacetate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 20.0h， 生成 3,6-di(azetidin-1-yl)acridine
  参考文献：
  名称：

  [EN] AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS
  [FR] COMPOSÉS FLUORESCENTS À SUBSTITUTION AZÉTIDINE

  摘要：

  目前公开的题材包括取代的荧光化合物，其中化合物可用作探针、染料、标签等。目前公开的题材还包括包含相同成分的试剂盒以及使用相同成分检测目标物质的方法。

  公开号：

  WO2015153813A1
• 作为产物：
  描述：

  4,4'-二氨基-2,2'-二硝基二苯基甲烷 在 盐酸 、 tin 、 硫酸 作用下， 生成 3,6-二羟基吖啶
  参考文献：
  名称：

  Benda, Chemische Berichte, 1912, vol. 45, p. 1796

  摘要：

  DOI：

文献信息

• Synthesis of 3,6-bis(aminoalkoxy)acridines and their effect on the immune system
  作者：Robert B. Angier、Ronald V. Citarella、Martin Damiani、Paul F. Fabio、Thomas L. Fields、Soon M. Kang、Yangi Lin、Howard F. Lindh、K. C. Murdock

  DOI：10.1021/jm00366a010

  日期：1983.12

  A series of 3,6-bis(aminoalkoxy)acridines (2) was prepared and shown to have a protective antiviral effect against an interferon-sensitive virus (Columbia SK) and to partially restore an antibody response to a T-cell-dependent antigen in leukemic immunosuppressed mice. The presence of circulating interferon and the stimulation of natural killer cell activity in mice was observed for 21.

  制备了一系列3,6-双（氨基烷氧基）ac啶（2），显示对干扰素敏感病毒（Columbia SK）具有保护性抗病毒作用，并部分恢复对T细胞依赖性抗原的抗体反应在白血病免疫抑制小鼠中。观察到21小鼠中循环干扰素的存在和自然杀伤细胞活性的刺激。
• Certain 3,6-bis-(heteroaminoalkoxy) acridines
  申请人：——

  公开号：US04314061A1

  公开（公告）日：1982-02-02

  This disclosure describes compositions of matter useful for inducing the regression of tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being certain 3,6-bis(aminoalkoxy)acridines or the pharmacologically acceptable acid-addition salts thereof.

  本公开说明了一种用于诱导温血动物肿瘤退化和增强免疫系统的物质组成，以及所述物质组成的活性成分为某些3,6-双（氨基烷氧基）蒽啉或其药理学上可接受的酸加成盐，用于治疗哺乳动物肿瘤和增强其免疫反应的方法。
• 3,6-bis (substituted) acridine N-oxides and N,N-dioxides and methods of
  申请人：American Cyanamid Company

  公开号：US04696936A1

  公开（公告）日：1987-09-29

  This invention concerns novel 3,6-bis(substituted) acridine N-oxides and N,N-dioxides which are active as modulators of the immune system in warm-blooded animals.

  这项发明涉及新型的3,6-双(取代基)蒽N-氧化物和N,N-二氧化物，它们在温血动物的免疫系统调节中具有活性。
• Substituted 3,6 bis-(aminoalkoxy)acridines, and a process for their preparation
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0031407A1

  公开（公告）日：1981-07-08

  Compounds selected from the group consisting of those of the formula: wherein n is the integer 1, 2 or 3; R1 and R2 are each hydrogen or methyl; R3 and R4 are the same or different and are hydrogen or straight chain or branched alkyl (C1-C4); and R3 and R4 taken together with the associated N(itro- gen) is pyrrolidino, piperidino, morpholino or N-methylpiperazino; and R5, R6 and R, may be the same or different and are selected from the group consisting of hydrogen, fluoro, chloro, bromo and nitro; with the proviso that when n is one or two and R, and R2 are hydrogen or methyl and R3 and R4 are lower alkyl then at least one of Rs, R6 and R7 must be a substituent other than hydrogen; the pharmacologically acceptable metal complexes thereof and the pharmacologically acceptable acid-addition salts thereof. A process for their preparation and compositions of matter useful for inducing the regression of tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being certain 3,6-bis(aminoalkoxy)acridines or the pharmacologically acceptable acidaddition salts thereof.

  选自由下列式子组成的化合物组 其中 n 为整数 1、2 或 3；R1 和 R2 分别为氢或甲基；R3 和 R4 相同或不同，且为氢或直链或支链烷基（C1-C4）；R3 和 R4 与相关的 N(itro-gen)合在一起为吡咯烷基、哌啶基、吗啉基或 N-甲基哌嗪基；R5、R6 和 R 可以相同或不同，且选自由氢、氟、氯、溴和硝基组成的组；但条件是，当 n 为 1 或 2，R 和 R2 为氢或甲基，R3 和 R4 为低级烷基时，Rs、R6 和 R7 中至少有一个必须是氢以外的取代基；其药理上可接受的金属络合物及其药理上可接受的酸加成盐。 一种用于诱导温血动物肿瘤消退和增强免疫系统的制备工艺和物质组合物，以及用其治疗肿瘤和增强哺乳动物免疫反应的方法，所述物质组合物的活性成分是某些3,6-双(氨基烷氧基)吖啶或其药理学上可接受的酸加成盐。
• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。