4,5,6-triphenyl-3(2H)-pyridazinethione | 95161-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,5,6-triphenyl-3(2H)-pyridazinethione
• 英文别名: 4,5,6-Triphenylpyridazine-3(2h)-thione；3,4,5-triphenyl-1H-pyridazine-6-thione
• CAS: 95161-23-2
• 化学式: C₂₂H₁₆N₂S
• 分子量: 340.448
• InChiKey: LBLGDKGQEWIDHT-UHFFFAOYSA-N

物化性质

• 熔点：
  250-251 °C(Solv: acetic acid (64-19-7))
• 沸点：
  513.4±60.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5,6-triphenyl-3(2H)-pyridazinethione 在 sodium hydroxide 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 6,7,8-triphenyl-2,3-dihydro-[1,2,4]triazolo[4,3-b]pyridazine-3-thione
  参考文献：
  名称：

  Deeb, Ali; Said, Said Ali, Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 11, p. 2795 - 2799

  摘要：

  DOI：
• 作为产物：
  描述：

  3-chloro-4,5,6-triphenylpyridazine 在 sodium hydroxide 、 硫脲 作用下， 生成 4,5,6-triphenyl-3(2H)-pyridazinethione
  参考文献：
  名称：

  Deeb, Ali; Said, Said Ali, Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 11, p. 2795 - 2799

  摘要：

  DOI：

文献信息

• Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety
  作者：Nicholas A. Meanwell、Michael J. Rosenfeld、Ashok K. Trehan、Jeffrey L. Romine、J. J. Kim Wright、Catherine L. Brassard、John O. Buchanan、Marianne E. Federici、J. Stuart Fleming、Marianne Gamberdella、George B. Zavoico、Steven M. Seiler

  DOI：10.1021/jm00097a007

  日期：1992.9

  4,5-Diphenyl-2-oxazolenonanoic acid (2) and 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (3) were previously identified as nonprostanoid prostacyclin (PGI2) mimetics that inhibit ADP-induced aggregation of human platelets in vitro. The effects on biological activity of substitution and structural modification of the 4- and 5-phenyl rings of 3 was examined. Potency showed a marked sensitivity

  4,5-二苯基-2-恶唑壬酸（2）和2- [3- [2-（4,5-二苯基-2-恶唑基）乙基]苯氧基]乙酸（3）先前被确定为非前列腺素前列环素（PGI2 ）在体外抑制ADP诱导的人类血小板聚集的模拟物。考察了3的4-和5-苯基环对取代和结构修饰的生物活性的影响。效能显示出对将取代基引入这些芳族环的显着敏感性，并且只有双-4-甲基衍生物9j（IC50 = 0.34 microM）与母体结构3（IC50 = 1.2 microM）相比具有增强的效能。在苯环的邻位或间位取代，被噻吩基或环己基部分取代，或限制在平面菲系统中产生的化合物不是ADP诱导的血小板聚集的有效抑制剂。相比之下，杂环部分的变化表明，SAR的严格性要低得多，并且发现许多5和6元杂环可有效替代2和3的恶唑环。二苯甲基部分可作为4,5-的有效等排体自13aad以来的二苯环杂环化合物显示出与3相似的血小板抑制活性。除了3,4,5-三苯基吡唑衍生物13g以外，与类似取代的3
• Pyridazine and its related compounds. Part 34. Hypoglycemic and hypolipidemic activity of some novel condensed pyridazine sulfonamides
  作者：Ali Deeb、Wafaa El-Eraky、Sally El-Awdan、Sebaey Mahgoub

  DOI：10.1007/s00044-013-0605-5

  日期：2014.1

  A novel class of sulfonylurea and thiourea derivatives substituted with pyridazine and triazolopyridazine were designed and synthesized. The target compounds were assayed for their effects on the insulin release of alloxan-induced diabetic rats. The results showed that derivatives 4a, 4c, 8a, 11a, and 11b have significant antihyperglycemic effect in an experimental model of diabetes mellitus. No significant differences in cholesterol levels were observed between the diabetic group and diabetic groups that received the test compounds. However, the triglycerides level was reduced significantly by compound 8a when compared with the diabetic group.
• DEEB, ALI;ALI, SAID SAID, COLLECT. CZECHOSL. CHEM. COMMUN., 55,(1990) N1, C. 2795-2799
  作者：DEEB, ALI、ALI, SAID SAID

  DOI：——

  日期：——