cis-2-Hydroxyethylcyclohex-2-enol | 64532-87-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis-2-Hydroxyethylcyclohex-2-enol
• 英文别名: (1R,6S)-6-(2-hydroxyethyl)cyclohex-2-en-1-ol
• CAS: 64532-87-2；114180-45-9
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: QSWCCEOQEHNJMP-YUMQZZPRSA-N

物化性质

• 沸点：
  263.1±23.0 °C(Predicted)
• 密度：
  1.078±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-2-Hydroxyethylcyclohex-2-enol 在 二正丁基氧化锡 、 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 9.0h， 生成 6-(2-((2-methoxybenzyl)oxy)ethyl)cyclohex-2-en-1-one
  参考文献：
  名称：

  Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells

  摘要：

  The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.006
• 作为产物：
  描述：

  (1R,2S)-acetic acid 6-formyl-cyclohex-2-enyl ester 在 盐酸 、 二异丁基氢化铝 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 5.0h， 生成 cis-2-Hydroxyethylcyclohex-2-enol
  参考文献：
  名称：

  Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells

  摘要：

  The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.006

文献信息

• Regioselective silylation of 5-(2′-hydroxyethyl)cyclopent-2-en-1-ol and 6-(2′-hydroxyethyl)cyclohex-2-en-1-ol
  作者：Hao Chen、Erika Plettner

  DOI：10.1016/j.tetlet.2012.02.020

  日期：2012.4

  Herein we report regioselective and mild reactions for the tert-butyldimethylsilyl mono-protection of 5-(2′-hydroxyethyl)cyclopent-2-en-1-ol (2) and 6-(2′-hydroxyethyl)cycohex-2-en-1-ol (5) at the primary hydroxyl group or at the secondary allylic hydroxyl group. The different steric environment surrounding the secondary allylic and saturated primary alcohols is mainly invoked to rationalize the observed

  在这里，我们报告5-（2'-羟乙基）环戊-2-en-1-ol（2）和6-（2'-羟乙基）cyhehex-2-en对叔丁基二甲基甲硅烷基单保护的区域选择性反应和温和反应在伯羟基或仲烯丙基羟基上的-1-醇（5）。围绕仲烯丙基和饱和伯醇的不同空间环境主要是为了使观察到的区域选择性合理化。
• A study of asymmetric induction during the addition of enolate nucleophiles, having sulfoximine chiral auxiliaries, to diene-molybdenum and dienyliron complexes
  作者：Anthony J. Pearson、Sheri L. Blystone、Herbert Nar、A. Alan Pinkerton、Brian A. Roden、Jaeyon Yoon

  DOI：10.1021/ja00183a024

  日期：1989.1
• Jones,J.B.; Goodbrand,H.B., Canadian Journal of Chemistry, 1977, vol. 55, p. 2685 - 2691
  作者：Jones,J.B.、Goodbrand,H.B.

  DOI：——

  日期：——