3-(1H-吡唑-1-基)丙酰肼 | 1177300-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-(1H-吡唑-1-基)丙酰肼
• 英文名称: 3-(1H-pyrazol-1-yl)propionic acid hydrazide
• 英文别名: 3-(1H-Pyrazol-1-yl)propanohydrazide；3-pyrazol-1-ylpropanehydrazide
• CAS: 1177300-40-1
• 化学式: C₆H₁₀N₄O
• mdl: MFCD12030827
• 分子量: 154.172
• InChiKey: XNZLTYISUNMPET-UHFFFAOYSA-N

物化性质

• 沸点：
  402.2±28.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933199090

反应信息

• 作为反应物：
  描述：

  3-(1H-吡唑-1-基)丙酰肼 、 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester iodomethylate 以 乙醇 为溶剂， 反应 36.0h， 以38%的产率得到ethyl 5,7-dimethyl-2-[2-(1H-pyrazol-1-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxylate
  参考文献：
  名称：

  Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts

  摘要：

  We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and D-pyrazolylsubstituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.

  DOI：

  10.1007/s10593-015-1724-3
• 作为产物：
  描述：

  3-(1H-吡唑-1-基)丙酸乙酯 在 一水合肼 作用下， 反应 0.17h， 以91%的产率得到3-(1H-吡唑-1-基)丙酰肼
  参考文献：
  名称：

  Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts

  摘要：

  We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and D-pyrazolylsubstituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.

  DOI：

  10.1007/s10593-015-1724-3

文献信息

• [EN] METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR<br/>[FR] PROCÉDÉS ET COMPOSITIONS ASSOCIÉS AU RÉCEPTEUR DU FACTEUR DE STIMULATION DES COLONIES DE GRANULOCYTES
  申请人：LIGAND PHARM INC

  公开号：WO2013074459A1

  公开（公告）日：2013-05-23

  Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

  一些实施例包括组成物和使用或识别调节粒细胞集落刺激因子受体（GCFR）活性的化合物的方法。一些实施例包括使用化合物来治疗某些疾病，如造血或神经系统疾病。
• Methods and compositions associated with the granulocyte colony-stimulating factor receptor
  申请人：Ligand Pharmaceuticals, Inc.

  公开号：US10111859B2

  公开（公告）日：2018-10-30

  Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

  一些实施方案包括使用或鉴定调节粒细胞集落刺激因子受体（GCFR）活性的化合物的组合物和方法。一些实施方案包括使用化合物治疗某些疾病，如造血或神经系统疾病。
• METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR
  申请人：Ligand Pharmaceuticals Inc.

  公开号：EP2780322A1

  公开（公告）日：2014-09-24
• US9492430B2
  申请人：——

  公开号：US9492430B2

  公开（公告）日：2016-11-15