trifluoro-acetic acid-(9-methyl-carbazol-3-ylamide) | 318-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: trifluoro-acetic acid-(9-methyl-carbazol-3-ylamide)
• 英文别名: Trifluor-essigsaeure-(9-methyl-carbazol-3-ylamid)；N-(9-Methyl-9H-carbazol-3-yl)-trifluoroacetamide；3-(Trifluoroacetylamino)-9-methyl-9H-carbazole；2,2,2-trifluoro-N-(9-methylcarbazol-3-yl)acetamide
• CAS: 318-11-6
• 化学式: C₁₅H₁₁F₃N₂O
• 分子量: 292.26
• InChiKey: IRNPBXOHJDFBQR-UHFFFAOYSA-N

物化性质

• 沸点：
  386.2±42.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  34
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  N-甲基咔唑 在 palladium on activated charcoal 氢气 、 硝酸 、 溶剂黄146 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 trifluoro-acetic acid-(9-methyl-carbazol-3-ylamide)
  参考文献：
  名称：

  Structure–activity relationships in a series of NPY Y5 antagonists: 3-amido-9-ethylcarbazoles, core-modified analogues and amide isosteres

  摘要：

  Beginning with carbazole la, the amide and alkyl substituents were optimized to maintain potency while adding solubilizing groups. Efforts to replace the 3-amino-9-ethylcarbazole core, a known carcinogen, used the SAR generated in the carbazole series for guidance and led to the synthesis of a number of core-modified analogues. In addition, an isosteric series, in which the amide was replaced with an imidazole, was prepared. Two potent new series lacking the putative toxicophore were identified from these endeavors. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00329-9

文献信息

• PYY and agonists thereof for modification of feeding behaviour
  申请人：Imperial Innovations Limited

  公开号：EP2050460A1

  公开（公告）日：2009-04-22

  Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

  本发明公开了减少受试者卡路里摄入量、食物摄入量和食欲的方法。 这些方法包括向受试者外周施用治疗有效量的PYY或其激动剂，从而减少受试者的卡路里摄入量。
• Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior
  申请人：Cowley Michael

  公开号：US20050015820A1

  公开（公告）日：2005-01-20

  Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

  本文公开了用于鉴定影响热量摄入、食物摄入、食欲和能量消耗的制剂的筛选方法。这些方法可用于鉴定治疗肥胖症或可用于减轻受试者体重的药物。这些方法还可用于确定治疗厌食症或恶病质的药物，并可用于增加食欲和增加受试者的体重和瘦体重。
• Synthesis and Ultraviolet Absorption Spectra Studies of 2,3- and 3,4-Disubstituted Carbazoles¹
  作者：Eugene Sawicki

  DOI：10.1021/ja01632a009

  日期：1954.2
• EP1499277A4
  申请人：——

  公开号：EP1499277A4

  公开（公告）日：2005-08-31
• MODIFICATION OF FEEDING BEHAVIOR
  申请人：Imperial College Innovations Limited

  公开号：EP1499277A2

  公开（公告）日：2005-01-26