2,4-Dimethoxy-6-hydrazinopyrimidin | 55908-81-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-Dimethoxy-6-hydrazinopyrimidin
• 英文别名: (2,6-Dimethoxypyrimidin-4-yl)hydrazine
• CAS: 55908-81-1
• 化学式: C₆H₁₀N₄O₂
• mdl: MFCD19201465
• 分子量: 170.171
• InChiKey: DXSHSVANDSXQNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  82.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-Nitro-3,4-diphenylfuran-2-carbaldehyde 、 2,4-Dimethoxy-6-hydrazinopyrimidin 以60%的产率得到
  参考文献：
  名称：

  YAMAMOTO KATSUMI; YOSHINA SHIGETAKA, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR. , 1975, 95+

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氯-2,4-甲氧基嘧啶 在 bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)] 、 N-[2-二(1-金刚烷)磷苯基]吗啉 、 一水合肼 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 2,4-Dimethoxy-6-hydrazinopyrimidin
  参考文献：
  名称：

  Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid

  摘要：

  N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochemical assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.11.022

文献信息

• Herbicidal alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamides
  申请人：DowElanco

  公开号：US05163995A1

  公开（公告）日：1992-11-17

  5-Alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamides are prepared from 5-alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonyl halides by condensation with ortho-substituted N-trialkylsilylanilines and by other methods. N-(2,6-dichloro-3-methylphenyl)-8-fluoro-5-methoxy-1,2,4-triazolo[1,5-c]py rimidine-2-sulfonamide is typical. The compounds are general and selective pre- and postemergence herbicides.

  5-烷氧基-1,2,4-三唑并[1,5-c]嘧啶-2-磺酰胺是通过与邻位取代的N-三烷基硅基苯胺和其他方法反应制备的。N-(2,6-二氯-3-甲基苯基)-8-氟-5-甲氧基-1,2,4-三唑并[1,5-c]嘧啶-2-磺酰胺是典型的化合物。这些化合物是一般和选择性的前后除草剂。
• Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates
  申请人：DowElanco

  公开号：EP0343752A1

  公开（公告）日：1989-11-29

  Alkoxy substituted 1,2,4-triazolo[1,5-c]­pyrimidine-2-sulfonamides are general and selective pre- and postemergence herbicides. These compounds are disclosed which are prepared from alkoxy substituted 1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonyl halides by condensation with substituted N-trialkylsilylanilines and by other methods.

  烷氧基取代的 1,2,4-三唑并[1,5-c]嘧啶-2-磺酰胺类化合物是一般的和选择性的芽前和芽后除草剂。已公开的这些化合物是由烷氧基取代的 1,2,4-三唑并[1,5-c]嘧啶-2-磺酰卤通过与取代的 N-三烷基硅烷胺缩合或通过其他方法制备而成。
• Process for producing biaryl compound
  申请人：Hagiya Koji

  公开号：US20050096471A1

  公开（公告）日：2005-05-05

  A process for producing a biaryl compound, characterized by reacting an arylhydrazine compound, hydrogen peroxide and an aryl compound. When the reaction is conducted in the presence of a given metal or a compound of the metal or in the presence of a metal oxide obtained by reacting the given metal or a compound of the metal with hydrogen peroxide, then the yield of the biaryl compound is improved.

  一种生产双芳基化合物的工艺，其特征在于使芳基肼化合物、过氧化氢和芳基化合物反应。当反应是在某种金属或金属化合物存在下进行，或在某种金属或金属化合物与过氧化氢反应得到的金属氧化物存在下进行时，双芳基化合物的产率会提高。
• PROCESS FOR PRODUCING BIARYL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1473286B1

  公开（公告）日：2009-11-04
• YOSHINA SHIGETAKA; YAMAMOTO KATSUMI, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR. <YKKZ-AJ>, 1975, 95+
  作者：YOSHINA SHIGETAKA、 YAMAMOTO KATSUMI

  DOI：——

  日期：——