18-chloro-3,6,9,12-tetraoxaoctadecane-1-aminium chloride | 1261238-20-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 18-chloro-3,6,9,12-tetraoxaoctadecane-1-aminium chloride
• 英文别名: 18-chloro-3,6,9,12-tetraoxaoctadecan-1-amine hydrochloride；18-Chloro-3,6,9,12-tetraoxaoctadecan-1-amine hydrochloride；2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethanamine;hydrochloride
• CAS: 1261238-20-3
• 化学式: C₁₄H₃₀ClNO₄*ClH
• 分子量: 348.31
• InChiKey: XKHLDTNJZBRALN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  21
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  18-chloro-3,6,9,12-tetraoxaoctadecane-1-aminium chloride 、 9-氟-11,17-二羟基-16alpha-甲基-3-氧代雄甾-1,4-二烯-17-羧酸 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以44 mg的产率得到
  参考文献：
  名称：

  タンパク質を官能基または固体表面に共有結合的に係留するための基質

  摘要：

  本发明提供了用于连接卤代烷基底物和这样的底物与功能元素（例如标签、标记、表面等）的连接体的链接剂。本说明书中所描述的基质和链接剂可用于蛋白质、细胞和分子的标记、检测和固定化等应用。特别地，本说明书提供的链接剂可用于与卤代烷基底物共同形成共价键的脱卤酶突变体内使用。【选图】无。

  公开号：

  JP2016521250A
• 作为产物：
  描述：

  tert-butyl N-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以96 %的产率得到18-chloro-3,6,9,12-tetraoxaoctadecane-1-aminium chloride
  参考文献：
  名称：

  INTRACELLULAR LIGATION OF PHOTOCATALYSTS FOR PHOTO-RESPONSIVE, PROBE-MEDIATED PROTEIN LABELING

  摘要：

  Embodiments of the present disclosure relate to methods, compositions, and systems for proximity-based, photoactivated labeling of molecules. Molecules may be labeled via activation of a ligated photocatalyst capable of transmitting energy to a proximal biomolecular labeling agent. Depending on the activated half-life and diffusion coefficient of the labeling agent, molecules within a particular vicinity of the ligated photocatalyst may be labeled but molecules outside the vicinity will not be labeled.

  公开号：

  WO2023245020A1

文献信息

• SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES
  申请人：PROMEGA CORPORATION

  公开号：US20140322794A1

  公开（公告）日：2014-10-30

  The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.

  本发明提供了卤代烷基底物和连接这种底物与功能元件（例如标签、标记、表面等）的连接物。本文所描述的底物和连接物可用于蛋白质、细胞和分子的标记、检测和固定等方面。特别是，本发明提供的连接物可用于卤代烷酶变体的底物中，这些变体与其卤代烷基底物形成共价键。
• Method of determining, identifying or isolating cell-penetrating peptides
  申请人：Phylogica Limited

  公开号：US10288601B2

  公开（公告）日：2019-05-14

  The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

  本发明提供了一种确定或鉴定或分离细胞穿透肽（CPP）或其类似物或衍生物的方法，该方法具有细胞类型选择性和/或至少能够通过动物主体的血脑屏障。本发明还提供了 CPP 及其类似物和衍生物，如序列表中 SEQ ID NOs: 1-27 所列的那些，以及包含一种或多种 CPP 的组合物，包括 CPP 或其类似物或衍生物与货物分子连接的共轭物。本发明还提供了将货物分子跨细胞膜运输到细胞内特定位置的方法，以及治疗、预防和/或诊断可通过附着本发明的 CPP 或类似物或衍生物的货物分子治疗的疾病的方法。本发明还提供了用于鉴定或分离 CPP 的定制肽库。
• Substrates for covalent tethering of proteins to functional groups or solid surfaces
  申请人：PROMEGA CORPORATION

  公开号：US11072812B2

  公开（公告）日：2021-07-27

  The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.

  本发明提供了卤代烃基底以及用于将此类基底与功能元件（如标签、标记、表面等）连接的连接体。本文所述的底物和连接体可用于蛋白质、细胞和分子的标记、检测和固定等。特别是，本文提供的连接体可用于与卤代烃底物形成共价键的脱卤酶变体的底物中。
• [EN] REACTIVE CYANINE COMPOUNDS<br/>[FR] COMPOSÉS DE CYANINE RÉACTIFS
  申请人：PROMEGA CORP

  公开号：WO2011026085A3

  公开（公告）日：2011-04-21
• Method of Determining, Identifying or Isolating Cell-Penetrating Peptides
  申请人：Watt Paul Michael

  公开号：US20140141452A1

  公开（公告）日：2014-05-22

  The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.