2-(3,3-dimethyl-1-phenylaziridin-2-yl)-4,4-dimethyl-5H-1,3-oxazole | 1027425-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(3,3-dimethyl-1-phenylaziridin-2-yl)-4,4-dimethyl-5H-1,3-oxazole
• CAS: 1027425-20-2
• 化学式: C₁₅H₂₀N₂O
• 分子量: 244.337
• InChiKey: WGUPWRIYNCKMFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  24.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3,3-dimethyl-1-phenylaziridin-2-yl)-4,4-dimethyl-5H-1,3-oxazole 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of oxazolinyl aziridines

  摘要：

  Aziridinyllithiums 4a and 4b, which are stable at low temperature, can be generated by deprotonation of 3a and 3b. Oxazolinyl aziridines 5a-j and 6a-b have been prepared by the reaction of oxazolinyl aziridinyllithiums 4a and 4b with electrophiles. Aziridines 6c and 6d were, instead, synthesized by a Darzens-like reaction from 2-(1-chloroethyl)-2-oxazoline 1b. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01212-5
• 作为产物：
  描述：

  N-(propan-2-ylidene)aniline 、 2-chloromethyl-4,4-dimethyl-4,5-dihydro-1,3-oxazole 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以40%的产率得到2-(3,3-dimethyl-1-phenylaziridin-2-yl)-4,4-dimethyl-5H-1,3-oxazole
  参考文献：
  名称：

  Synthesis of oxazolinyl aziridines

  摘要：

  Aziridinyllithiums 4a and 4b, which are stable at low temperature, can be generated by deprotonation of 3a and 3b. Oxazolinyl aziridines 5a-j and 6a-b have been prepared by the reaction of oxazolinyl aziridinyllithiums 4a and 4b with electrophiles. Aziridines 6c and 6d were, instead, synthesized by a Darzens-like reaction from 2-(1-chloroethyl)-2-oxazoline 1b. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01212-5