5-(2-furyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole | 905844-08-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2-furyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole
• 英文别名: 3-trifluoromethyl-5-(2-furyl)-1-methylpyrazole；5-(furan-2-yl)-1-methyl-3-(trifluoromethyl)pyrazole
• CAS: 905844-08-8
• 化学式: C₉H₇F₃N₂O
• 分子量: 216.163
• InChiKey: GKRNOOAMDPOHJY-UHFFFAOYSA-N

物化性质

• 沸点：
  255.6±40.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  31
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(2-furyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole 在 sodium hydroxide 、 正丁基锂 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 、 水 为溶剂， 生成 5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)furan-2-carboxylic acid
  参考文献：
  名称：

  Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles

  摘要：

  To identify potent and selective calcium-release-activated calcium (CRAG) channel inhibitors, we examined the structure-activity relationships of the pyrazole and thiophene moieties in compound 4. Compound 25b was found to exhibit highly potent and selective inhibitory activity for CRAC channels and further modifications of the pyrazole and benzoyl moieties of compound 25b produced compound 29. These compounds were potent inhibitors of IL-2 production in vitro and also acted as inhibitors in pharmacological models of diseases resulting from T-lymphocyte activation, after oral administration. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.03.039
• 作为产物：
  描述：

  2-乙酰基呋喃 在 sodium methylate 、 溶剂黄146 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 38.0h， 生成 5-(2-furyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole
  参考文献：
  名称：

  Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles

  摘要：

  To identify potent and selective calcium-release-activated calcium (CRAG) channel inhibitors, we examined the structure-activity relationships of the pyrazole and thiophene moieties in compound 4. Compound 25b was found to exhibit highly potent and selective inhibitory activity for CRAC channels and further modifications of the pyrazole and benzoyl moieties of compound 25b produced compound 29. These compounds were potent inhibitors of IL-2 production in vitro and also acted as inhibitors in pharmacological models of diseases resulting from T-lymphocyte activation, after oral administration. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.03.039

文献信息

• Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-trifluoropropene
  作者：Chuanle Zhu、Hao Zeng、Chi Liu、Yingying Cai、Xiaojie Fang、Huanfeng Jiang

  DOI：10.1021/acs.orglett.9b04228

  日期：2020.2.7

  is reported that occurs by the three-component coupling of environmentally friendly and large-tonnage industrial feedstock 2-bromo-3,3,3-trifluoropropene (BTP), aldehydes, and sulfonyl hydrazides. This highly regioselective three-component reaction is metal-free, catalyst-free, and operationally simple and features mild conditions, a broad substrate scope, high yields, and valuable functional group

  据报道，通过环境友好的大吨位工业原料2-溴-3,3,3-三氟丙烯（BTP），醛和磺酰肼的三组分偶联，可以实现3-三氟甲基吡唑合成的通用和实用策略。这种高度区域选择性的三组分反应不含金属，不含催化剂，操作简单，具有条件温和，底物范围广，收率高和有价值的官能团耐受性。值得注意的是，反应可以在100 mmol的规模上进行，并顺利提供了塞来昔布，马伐昔布，SC-560和AS-136A合成的关键中间体。初步机理研究表明，此转化过程涉及1,3-氢原子转移过程。
• Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA
  作者：Raquel Román、Antonio Navarro、Dariusz Wodka、Maria Alvim-Gaston、Saba Husain、Natalie Franklin、Antonio Simón-Fuentes、Santos Fustero

  DOI：10.1021/op500114v

  日期：2014.8.15
• Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs
  作者：Santos Fustero、Raquel Román、Juan F. Sanz-Cervera、Antonio Simón-Fuentes、Ana C. Cuñat、Salvador Villanova、Marcelo Murguía

  DOI：10.1021/jo800251g

  日期：2008.5.1

  The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric mixtures of N-methylpyrazoles, which sometimes are difficult to separate. We have determined that the use of fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation, and we have used this modification in a straightforward synthesis of fluorinated analogs of Tebufenpyrad with acaricide activity.