3-(9-methyl-9H-carbazol-3-yl)-1-phenylpropenone | 32059-76-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(9-methyl-9H-carbazol-3-yl)-1-phenylpropenone
• 英文别名: 3-(9-methyl-carbazol-3-yl)-1-phenyl-propenone；1-(9-Methyl-3-carbazolyl)-2-benzoylethylen；3-(9-Methyl-9H-carbazol-3-yl)-1-phenyl-2-propen-1-one；3-(9-methylcarbazol-3-yl)-1-phenylprop-2-en-1-one
• CAS: 32059-76-0
• 化学式: C₂₂H₁₇NO
• 分子量: 311.383
• InChiKey: KQNFNMPCJUBMDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(9-methyl-9H-carbazol-3-yl)-1-phenylpropenone 在 一水合肼 作用下， 以 乙醇 为溶剂， 以78%的产率得到9-methyl-3-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-9H-carbazole
  参考文献：
  名称：

  Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents

  摘要：

  A novel series of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines (5a-o) has been synthesized and the structures of newly synthesized compounds were characterized by IR, H-1 NMR and mass spectral analysis. All the synthesized compounds were evaluated for their in vitro and in vivo anti-inflammatory activity, and also for their antioxidant activity. Compounds 5b, 5c, 5d and 5n were found to be selective COX-2 inhibitors. Compound 5c was found to potent inhibitor of the carrageenin induced paw edema in rats. Most of the compounds exhibited good DPPH and superoxide radical scavenging activity, while compounds 5c, 5d, 5i and 5k exhibited good hydroxyl radical scavenging activity. Molecular docking result, along with the biological assay data, suggested that compound 5c was a potential anti-inflammatory agent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.080
• 作为产物：
  描述：

  N-甲基咔唑 在 sodium hydroxide 、 三氯氧磷 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 3-(9-methyl-9H-carbazol-3-yl)-1-phenylpropenone
  参考文献：
  名称：

  Synthesis of novel carbazole chalcones as radical scavenger, antimicrobial and cancer chemopreventive agents

  摘要：

  A series of novel carbazole chalcones has been synthesised and evaluated for radical scavenging activity, cytotoxicity and antimicrobial activities. Compounds 12m, 12o and 12c exhibited good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, compounds 12e, 12m and 12d were excellent hydroxyl radical scavengers and compounds 12a, 12e, 12g, 12n and 12m have shown inhibition of oxidative DNA damage induced by 2,2'-azobis (2-amidinopropane hydrochloride). Compounds 12j, 12i, 12n, 12c, 12m and 12e were most active against the selected cancer cell lines. Compounds 12a, 12e and 12m showed good antibacterial activity and compounds 12h and 12m have shown good antifungal activity. All the compounds were subjected for absorption, distribution, metabolism and excretion (ADME) predictions by computational method and found that these molecules could be considered as potential candidates for oral drug development.

  DOI：

  10.3109/14756366.2012.663365

文献信息

• Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents
  作者：Laxman K. Adsul、Babasaheb P. Bandgar、Hemant V. Chavan、Shivkumar S. Jalde、Valmik D. Dhakane、Amol L. Shirfule

  DOI：10.3109/14756366.2012.740477

  日期：2013.12.1

  A novel series of carbazole substituted aminopyrimidines (5a-p) were synthesized and screened for their in vitro urease inhibition and antimicrobial activity. Among the compounds, 4-(2,4-dichlorophenyl)-6-(9-methyl-9H-carbazol-3-yl)-pyrimidin-2-amine (5i) was found to be the most potent showing urease inhibitory activity with an IC50 value 19.4 +/- 0.43 mu M. Compounds 5c, 5g, 5j and 5o showed good activity against all selected bacterial strains and compounds 5b, 5c, 5m and 5o showed good activity against selected fungal strains. All the compounds were subjected for ADME predictions by computational method.
• Synthesis of novel carbazole chalcones as radical scavenger, antimicrobial and cancer chemopreventive agents
  作者：Babasaheb P. Bandgar、Laxman K. Adsul、Shrikant V. Lonikar、Hemant V. Chavan、Sadanand N. Shringare、Sachin A. Patil、Shivkumar S. Jalde、Basawaraj A. Koti、Nagesh A. Dhole、Rajesh N. Gacche、Amol Shirfule

  DOI：10.3109/14756366.2012.663365

  日期：2013.6.1

  A series of novel carbazole chalcones has been synthesised and evaluated for radical scavenging activity, cytotoxicity and antimicrobial activities. Compounds 12m, 12o and 12c exhibited good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, compounds 12e, 12m and 12d were excellent hydroxyl radical scavengers and compounds 12a, 12e, 12g, 12n and 12m have shown inhibition of oxidative DNA damage induced by 2,2'-azobis (2-amidinopropane hydrochloride). Compounds 12j, 12i, 12n, 12c, 12m and 12e were most active against the selected cancer cell lines. Compounds 12a, 12e and 12m showed good antibacterial activity and compounds 12h and 12m have shown good antifungal activity. All the compounds were subjected for absorption, distribution, metabolism and excretion (ADME) predictions by computational method and found that these molecules could be considered as potential candidates for oral drug development.
• Synthesis, biological evaluation, and docking studies of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines as potent anti-inflammatory and antioxidant agents
  作者：Babasaheb P. Bandgar、Laxman K. Adsul、Hemant V. Chavan、Shivkumar S. Jalde、Sadanand N. Shringare、Rafique Shaikh、Rohan J. Meshram、Rajesh N. Gacche、Vijay Masand

  DOI：10.1016/j.bmcl.2012.07.080

  日期：2012.9

  A novel series of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2-pyrazolines (5a-o) has been synthesized and the structures of newly synthesized compounds were characterized by IR, H-1 NMR and mass spectral analysis. All the synthesized compounds were evaluated for their in vitro and in vivo anti-inflammatory activity, and also for their antioxidant activity. Compounds 5b, 5c, 5d and 5n were found to be selective COX-2 inhibitors. Compound 5c was found to potent inhibitor of the carrageenin induced paw edema in rats. Most of the compounds exhibited good DPPH and superoxide radical scavenging activity, while compounds 5c, 5d, 5i and 5k exhibited good hydroxyl radical scavenging activity. Molecular docking result, along with the biological assay data, suggested that compound 5c was a potential anti-inflammatory agent. (C) 2012 Elsevier Ltd. All rights reserved.